SP100 (SP100 nuclear antigen)

2007-02-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
lysp100b
FUSION GENES

Other Information

Locus ID:

NCBI: 6672
MIM: 604585
HGNC: 11206
Ensembl: ENSG00000067066

Variants:

dbSNP: 6672
ClinVar: 6672
TCGA: ENSG00000067066
COSMIC: SP100

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000067066ENST00000264052P23497
ENSG00000067066ENST00000340126P23497
ENSG00000067066ENST00000409112P23497
ENSG00000067066ENST00000409341P23497
ENSG00000067066ENST00000409824E9PHV6
ENSG00000067066ENST00000409897P23497
ENSG00000067066ENST00000413284H7C1G8
ENSG00000067066ENST00000427101P23497
ENSG00000067066ENST00000431952H0Y4R8
ENSG00000067066ENST00000432979C9JBL0
ENSG00000067066ENST00000452345H7C4B4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232215612013Components of promyelocytic leukemia nuclear bodies (ND10) act cooperatively to repress herpesvirus infection.56
168732582006Differential role of Sp100 isoforms in interferon-mediated repression of herpes simplex virus type 1 immediate-early protein expression.45
201301402010Three-dimensional organization of promyelocytic leukemia nuclear bodies.42
161778242005Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100.40
218807682011Human cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expression.36
217340362011Evidence for a dual antiviral role of the major nuclear domain 10 component Sp100 during the immediate-early and late phases of the human cytomegalovirus replication cycle.34
214713112011Human cytomegalovirus immediate-early gene expression is restricted by the nuclear domain 10 component Sp100.32
241945422013Sp100 provides intrinsic immunity against human papillomavirus infection.30
260571662015Contribution of the Major ND10 Proteins PML, hDaxx and Sp100 to the Regulation of Human Cytomegalovirus Latency and Lytic Replication in the Monocytic Cell Line THP-1.30
222782482012Herpesvirus saimiri antagonizes nuclear domain 10-instituted intrinsic immunity via an ORF3-mediated selective degradation of cellular protein Sp100.24

Citation

Dessen P

SP100 (SP100 nuclear antigen)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46310/sp100