SP110 (SP110 nuclear body protein)

2018-02-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
IFI41,IFI75,IPR1,VODI
FUSION GENES

Other Information

Locus ID:

NCBI: 3431
MIM: 604457
HGNC: 5401
Ensembl: ENSG00000135899

Variants:

dbSNP: 3431
ClinVar: 3431
TCGA: ENSG00000135899
COSMIC: SP110

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135899ENST00000258381Q9HB58
ENSG00000135899ENST00000258382Q9HB58
ENSG00000135899ENST00000358662Q9HB58
ENSG00000135899ENST00000392048G5E9C0
ENSG00000135899ENST00000409815E7EM70
ENSG00000135899ENST00000455674C9JZQ4
ENSG00000135899ENST00000540870Q9HB58

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169600082006An antigen produced by splicing of noncontiguous peptides in the reverse order.61
203313782010Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.29
168039592006Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa.27
153087352004Epstein-Barr virus (EBV) SM protein induces and recruits cellular Sp110b to stabilize mRNAs and enhance EBV lytic gene expression.26
168160192006No associations of human pulmonary tuberculosis with Sp110 variants.23
168160192006No associations of human pulmonary tuberculosis with Sp110 variants.23
145599982003Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus.22
201968682010Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.22
166488512006Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease.19
150637622004Genetic variations in humans associated with differences in the course of hepatitis C.16

Citation

Dessen P

SP110 (SP110 nuclear body protein)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57334/sp110