SPANXA1 (sperm protein associated with the nucleus, X-linked, family member A1)

2003-06-01  

Identity

HGNC
SPANXA1
LOCATION
Xq27.2
LOCUSID
30014
ALIAS
CT11.1,CT11.3,NAP-X,SPAN-X,SPAN-Xa,SPAN-Xb,SPANX,SPANX-A

Other Information

Locus ID:

NCBI: 30014
MIM: 300305
HGNC: 11218
Ensembl: ENSG00000198021

Variants:

dbSNP: 30014
ClinVar: 30014
TCGA: ENSG00000198021
COSMIC: SPANXA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198021ENST00000370519Q9NS26

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
268951022016The cancer-testis antigens SPANX-A/C/D and CTAG2 promote breast cancer invasion.18
147344582004Genomic organization, incidence, and localization of the SPAN-x family of cancer-testis antigens in melanoma tumors and cell lines.16
109060522000Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa.14
273238312016SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma.8
163904982006Expression of SpanX proteins in normal testes and in testicular germ cell tumours.3
200739422010SPANX gene variation in fertile and infertile males.3

Citation

Dessen P

SPANXA1 (sperm protein associated with the nucleus, X-linked, family member A1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42362/spanxa1