SPATA13 (spermatogenesis associated 13)

2006-10-01  

Identity

HGNC
SPATA13
LOCATION
13q12.12
LOCUSID
221178
ALIAS
ARHGEF29,ASEF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 221178
MIM: 613324
HGNC: 23222
Ensembl: ENSG00000273167

Variants:

dbSNP: 221178
ClinVar: 221178
TCGA: ENSG00000273167
COSMIC: SPATA13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000273167ENST00000382141A0A0A0MRY4

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810

References

Pubmed IDYearTitleCitations
175990592007Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42.34
199342212009The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration.28
191517592009Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.15
241447002013Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagen.11
199105432010Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke.6
248746042014Phosphorylation of serine 106 in Asef2 regulates cell migration and adhesion turnover.2

Citation

Dessen P

SPATA13 (spermatogenesis associated 13)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43501/spata13