SPC25 (SPC25 component of NDC80 kinetochore complex)

2017-10-01  

Identity

HGNC
LOCATION
2q24.3
LOCUSID
ALIAS
AD024,SPBC25,hSpc25
FUSION GENES

Other Information

Locus ID:

NCBI: 57405
MIM: 609395
HGNC: 24031
Ensembl: ENSG00000152253

Variants:

dbSNP: 57405
ClinVar: 57405
TCGA: ENSG00000152253
COSMIC: SPC25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152253ENST00000282074Q9HBM1
ENSG00000152253ENST00000451987C9JW94

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159614012005Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore.83
146991292004Identification of two novel components of the human NDC80 kinetochore complex.48
271972032016Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth.32
297094772018Spindle pole body component 25 homolog expressed by ECM stiffening is required for lung cancer cell proliferation.10
294329942018SPC25 upregulation increases cancer stem cell properties in non-small cell lung adenocarcinoma cells and independently predicts poor survival.8
304087712018Spindle pole body component 25 regulates stemness of prostate cancer cells.4

Citation

Dessen P

SPC25 (SPC25 component of NDC80 kinetochore complex)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57130/spc25