Identity
HGNC
LOCATION
2p23.2
LOCUSID
ALIAS
RINGO3,RINGOA,SPDY1,SPY1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 245711
MIM: 614029
HGNC: 30613
Ensembl: ENSG00000163806
Variants:
dbSNP: 245711
ClinVar: 245711
TCGA: ENSG00000163806
COSMIC: SPDYA
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Progesterone-mediated oocyte maturation | KEGG | ko04914 |
| Progesterone-mediated oocyte maturation | KEGG | hsa04914 |
| Oocyte meiosis | KEGG | ko04114 |
| Oocyte meiosis | KEGG | hsa04114 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34039995 | 2021 | The SUN1-SPDYA interaction plays an essential role in meiosis prophase I. | 10 |
| 34039995 | 2021 | The SUN1-SPDYA interaction plays an essential role in meiosis prophase I. | 10 |
| 32602013 | 2020 | Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT pathways in SH-SY5Y neuroblastoma cells. | 1 |
| 32691165 | 2020 | Salicylidene acylhydrazides attenuate survival of SH-SY5Y neuroblastoma cells through affecting mitotic regulator Speedy/RINGO and ERK/MAPK-PI3K/AKT signaling. | 1 |
| 32602013 | 2020 | Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT pathways in SH-SY5Y neuroblastoma cells. | 1 |
| 32691165 | 2020 | Salicylidene acylhydrazides attenuate survival of SH-SY5Y neuroblastoma cells through affecting mitotic regulator Speedy/RINGO and ERK/MAPK-PI3K/AKT signaling. | 1 |
| 31829284 | 2019 | The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis. | 7 |
| 31829284 | 2019 | The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis. | 7 |
| 28423577 | 2017 | The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance. | 9 |
| 28666995 | 2017 | Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. | 22 |
| 28423577 | 2017 | The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance. | 9 |
| 28666995 | 2017 | Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. | 22 |
| 25526860 | 2016 | CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush. | 9 |
| 26644004 | 2016 | Spy1 participates in the proliferation and apoptosis of epithelial ovarian cancer. | 3 |
| 25526860 | 2016 | CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush. | 9 |
Citation
Dessen P
SPDYA (speedy/RINGO cell cycle regulator family member A)
Atlas Genet Cytogenet Oncol Haematol. 2009-03-01
Online version: http://atlasgeneticsoncology.org/gene/50681/spdya
