SPIN1 (spindlin 1)

2007-02-01  

Identity

HGNC
SPIN1
LOCATION
9q22.1
LOCUSID
10927
ALIAS
SPIN,TDRD24
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10927
MIM: 609936
HGNC: 11243
Ensembl: ENSG00000106723

Variants:

dbSNP: 10927
ClinVar: 10927
TCGA: ENSG00000106723
COSMIC: SPIN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106723ENST00000375859Q9Y657
ENSG00000106723ENST00000375859A0A024R297

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
271714982016Suppression of SPIN1-mediated PI3K-Akt pathway by miR-489 increases chemosensitivity in breast cancer.32
219600062011Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes.27
245895512014Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1.23
230772552012Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1.19
257493822015The histone code reader SPIN1 controls RET signaling in liposarcoma.17
222587662012SPINDLIN1 promotes cancer cell proliferation through activation of WNT/TCF-4 signaling.16
170821822007Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation.15
160989132005Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells.13
182018432008Overexpression of SPINDLIN1 induces cellular senescence, multinucleation and apoptosis.13
185432482008Overexpression of spindlin1 induces metaphase arrest and chromosomal instability.12

Citation

Dessen P

SPIN1 (spindlin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45690/spin1