SPINK6 (serine peptidase inhibitor Kazal type 6)

2017-10-01  

Identity

HGNC
SPINK6
LOCATION
5q32
LOCUSID
404203
ALIAS
BUSI2,UNQ844
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 404203
MIM: 615868
HGNC: 29486
Ensembl: ENSG00000178172

Variants:

dbSNP: 404203
ClinVar: 404203
TCGA: ENSG00000178172
COSMIC: SPINK6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178172ENST00000325630Q6UWN8
ENSG00000178172ENST00000514389D6RGX9
ENSG00000178172ENST00000621437Q6UWN8

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
276716772017SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor.12
214393402011Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6.11
206678192010Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases.0
233034472013Cross-linking of SPINK6 by transglutaminases protects from epidermal proteases.0
243520402014Characterization of Spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury.0
268282692016The solution structure of the kallikrein-related peptidases inhibitor SPINK6.0
273542802016Gingipains of Porphyromonas gingivalis Affect the Stability and Function of Serine Protease Inhibitor of Kazal-type 6 (SPINK6), a Tissue Inhibitor of Human Kallikreins.0
279992032017Serine protease inhibitor kazal-type 6 inhibits tumorigenesis of human hepatocellular carcinoma cells via its extracellular action.0

Citation

Dessen P

SPINK6 (serine peptidase inhibitor Kazal type 6)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57134/spink6