SPINK9 (serine peptidase inhibitor Kazal type 9)

2014-11-01 Affiliation

Identity

HGNC

SPINK9

LOCATION

5q32

LOCUSID

643394

ALIAS

LEKTI2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 643394
MIM: 613511
HGNC: 32951
Ensembl: ENSG00000204909

Variants:

dbSNP: 643394
ClinVar: 643394
TCGA: ENSG00000204909
COSMIC: SPINK9

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204909	ENST00000377906	Q5DT21
ENSG00000204909	ENST00000511717	D6RJC5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Developmental Biology	REACTOME	R-HSA-1266738
Keratinization	REACTOME	R-HSA-6805567
Formation of the cornified envelope	REACTOME	R-HSA-6809371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title
19190773	2009	Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor.
19194479	2009	SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor.
21899598	2011	Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2.
22505519	2012	Characterization of SPINK9, a KLK5-specific inhibitor expressed in palmo-plantar epidermis.
24441102	2014	SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation.

Citation

Dessen P

SPINK9 (serine peptidase inhibitor Kazal type 9)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74186/spink9