SPIRE1 (spire type actin nucleation factor 1)

2018-11-01  

Identity

HGNC
SPIRE1
LOCATION
18p11.21
LOCUSID
56907
ALIAS
Spir-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56907
MIM: 609216
HGNC: 30622
Ensembl: ENSG00000134278

Variants:

dbSNP: 56907
ClinVar: 56907
TCGA: ENSG00000134278
COSMIC: SPIRE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134278ENST00000309836J3KNG6
ENSG00000134278ENST00000409402Q08AE8
ENSG00000134278ENST00000410092Q08AE8
ENSG00000134278ENST00000440472Q08AE8
ENSG00000134278ENST00000449797C9JYR7
ENSG00000134278ENST00000453447Q08AE8
ENSG00000134278ENST00000462226K7EQR2
ENSG00000134278ENST00000497844K7ENV1
ENSG00000134278ENST00000592156K7EMJ7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Dorso-ventral axis formationKEGGko04320
Dorso-ventral axis formationKEGGhsa04320

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
263055002015A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division.62
262874802015DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected].54
180424522007Analysis of the function of Spire in actin assembly and its synergy with formin and profilin.45
245861102014Spire and Formin 2 synergize and antagonize in regulating actin assembly in meiosis by a ping-pong mechanism.31
196053602009Identification of a short Spir interaction sequence at the C-terminal end of formin subgroup proteins.28
217058042011Molecular basis of actin nucleation factor cooperativity: crystal structure of the Spir-1 kinase non-catalytic C-lobe domain (KIND)•formin-2 formin SPIR interaction motif (FSI) complex.20
242135282014Spire-1 contributes to the invadosome and its associated invasive properties.10
276271282016A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion.7
266683262016Role of the C-terminal Extension of Formin 2 in Its Activation by Spire Protein and Processive Assembly of Actin Filaments.2

Citation

Dessen P

SPIRE1 (spire type actin nucleation factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57756/spire1