SPIRE2 (spire type actin nucleation factor 2)

2016-10-01  

Identity

HGNC
SPIRE2
LOCATION
16q24.3
LOCUSID
84501
ALIAS
Spir-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84501
MIM: 609217
HGNC: 30623
Ensembl: ENSG00000204991

Variants:

dbSNP: 84501
ClinVar: 84501
TCGA: ENSG00000204991
COSMIC: SPIRE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204991ENST00000378247Q8WWL2
ENSG00000204991ENST00000393062Q8WWL2
ENSG00000204991ENST00000563972H3BV39
ENSG00000204991ENST00000566337H3BV74

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Dorso-ventral axis formationKEGGko04320
Dorso-ventral axis formationKEGGhsa04320

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
262874802015DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected].54
196053602009Identification of a short Spir interaction sequence at the C-terminal end of formin subgroup proteins.28
255646072015Membrane targeting of the Spir·formin actin nucleator complex requires a sequential handshake of polar interactions.7
276271282016A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion.7

Citation

Dessen P

SPIRE2 (spire type actin nucleation factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56103/spire2