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SPO11 (SPO11 initiator of meiotic double stranded breaks)

Identity

Alias_namesSPO11, meiotic protein covalently bound to DSB (S. cerevisiae)-like
SPO11 meiotic protein covalently bound to DSB-like (S. cerevisiae)
SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
SPO11 meiotic protein covalently bound to DSB
Alias_symbol (synonym)CT35
SPATA43
TOPVIA
Other alias
HGNC (Hugo) SPO11
LocusID (NCBI) 23626
Atlas_Id 56743
Location 20q13.31  [Link to chromosome band 20q13]
Location_base_pair Starts at 57329775 and ends at 57343993 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RBM38 (20q13.31) / SPO11 (20q13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  RBM38/SPO11 (20q13)

External links

Nomenclature
HGNC (Hugo)SPO11   11250
Cards
Entrez_Gene (NCBI)SPO11  23626  SPO11 initiator of meiotic double stranded breaks
AliasesCT35; SPATA43; TOPVIA
GeneCards (Weizmann)SPO11
Ensembl hg19 (Hinxton)ENSG00000054796 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000054796 [Gene_View]  ENSG00000054796 [Sequence]  chr20:57329775-57343993 [Contig_View]  SPO11 [Vega]
ICGC DataPortalENSG00000054796
TCGA cBioPortalSPO11
AceView (NCBI)SPO11
Genatlas (Paris)SPO11
WikiGenes23626
SOURCE (Princeton)SPO11
Genetics Home Reference (NIH)SPO11
Genomic and cartography
GoldenPath hg38 (UCSC)SPO11  -     chr20:57329775-57343993 +  20q13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPO11  -     20q13.31   [Description]    (hg19-Feb_2009)
GoldenPathSPO11 - 20q13.31 [CytoView hg19]  SPO11 - 20q13.31 [CytoView hg38]
ImmunoBaseENSG00000054796
Mapping of homologs : NCBISPO11 [Mapview hg19]  SPO11 [Mapview hg38]
OMIM605114   
Gene and transcription
Genbank (Entrez)AF149310 AF169385 BC033591
RefSeq transcript (Entrez)NM_012444 NM_198265
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPO11
Cluster EST : UnigeneHs.159737 [ NCBI ]
CGAP (NCI)Hs.159737
Alternative Splicing GalleryENSG00000054796
Gene ExpressionSPO11 [ NCBI-GEO ]   SPO11 [ EBI - ARRAY_EXPRESS ]   SPO11 [ SEEK ]   SPO11 [ MEM ]
Gene Expression Viewer (FireBrowse)SPO11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23626
GTEX Portal (Tissue expression)SPO11
Human Protein AtlasENSG00000054796-SPO11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5K1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5K1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5K1
Splice isoforms : SwissVarQ9Y5K1
PhosPhoSitePlusQ9Y5K1
Domains : Interpro (EBI)Meiosis_Spo11    Meiotic_Spo11    Spo11/TopoVI_A    Spo11/TopoVI_A_N    Spo11/TopoVI_A_sf    TOPRIM_Topo6A/Spo11    WH-like_DNA-bd_sf   
Domain families : Pfam (Sanger)SPO11_like (PF03533)    TP6A_N (PF04406)   
Domain families : Pfam (NCBI)pfam03533    pfam04406   
Conserved Domain (NCBI)SPO11
DMDM Disease mutations23626
Blocks (Seattle)SPO11
SuperfamilyQ9Y5K1
Human Protein Atlas [tissue]ENSG00000054796-SPO11 [tissue]
Peptide AtlasQ9Y5K1
IPIIPI00843905   IPI00181896   IPI00514616   IPI00641521   IPI00647244   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5K1
IntAct (EBI)Q9Y5K1
FunCoupENSG00000054796
BioGRIDSPO11
STRING (EMBL)SPO11
ZODIACSPO11
Ontologies - Pathways
QuickGOQ9Y5K1
Ontology : AmiGOmeiotic DNA double-strand break processing  DNA catabolic process, endonucleolytic  chromosome, telomeric region  ovarian follicle development  DNA binding  protein binding  ATP binding  nucleus  synaptonemal complex assembly  reciprocal meiotic recombination  male meiosis I  spermatogenesis  spermatid development  female gamete generation  isomerase activity  endodeoxyribonuclease activity, producing 3'-phosphomonoesters  protein localization to chromosome  meiotic DNA double-strand break formation  meiotic telomere clustering  metal ion binding  oogenesis  double-strand break repair involved in meiotic recombination  
Ontology : EGO-EBImeiotic DNA double-strand break processing  DNA catabolic process, endonucleolytic  chromosome, telomeric region  ovarian follicle development  DNA binding  protein binding  ATP binding  nucleus  synaptonemal complex assembly  reciprocal meiotic recombination  male meiosis I  spermatogenesis  spermatid development  female gamete generation  isomerase activity  endodeoxyribonuclease activity, producing 3'-phosphomonoesters  protein localization to chromosome  meiotic DNA double-strand break formation  meiotic telomere clustering  metal ion binding  oogenesis  double-strand break repair involved in meiotic recombination  
NDEx NetworkSPO11
Atlas of Cancer Signalling NetworkSPO11
Wikipedia pathwaysSPO11
Orthology - Evolution
OrthoDB23626
GeneTree (enSembl)ENSG00000054796
Phylogenetic Trees/Animal Genes : TreeFamSPO11
HOGENOMQ9Y5K1
Homologs : HomoloGeneSPO11
Homology/Alignments : Family Browser (UCSC)SPO11
Gene fusions - Rearrangements
Fusion : QuiverSPO11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPO11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPO11
dbVarSPO11
ClinVarSPO11
1000_GenomesSPO11 
Exome Variant ServerSPO11
ExAC (Exome Aggregation Consortium)ENSG00000054796
GNOMAD BrowserENSG00000054796
Varsome BrowserSPO11
Genetic variants : HAPMAP23626
Genomic Variants (DGV)SPO11 [DGVbeta]
DECIPHERSPO11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPO11 
Mutations
ICGC Data PortalSPO11 
TCGA Data PortalSPO11 
Broad Tumor PortalSPO11
OASIS PortalSPO11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPO11  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSPO11
Mutations and Diseases : HGMDSPO11
BioMutasearch SPO11
DgiDB (Drug Gene Interaction Database)SPO11
DoCM (Curated mutations)SPO11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPO11 (select a term)
intoGenSPO11
Cancer3DSPO11(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605114   
Orphanet
DisGeNETSPO11
MedgenSPO11
Genetic Testing Registry SPO11
NextProtQ9Y5K1 [Medical]
TSGene23626
GENETestsSPO11
Target ValidationSPO11
Huge Navigator SPO11 [HugePedia]
snp3D : Map Gene to Disease23626
BioCentury BCIQSPO11
ClinGenSPO11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23626
Chemical/Pharm GKB GenePA36080
Clinical trialSPO11
Miscellaneous
canSAR (ICR)SPO11 (select the gene name)
DataMed IndexSPO11
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPO11
EVEXSPO11
GoPubMedSPO11
iHOPSPO11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:09:21 CET 2019
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