| Nomenclature |
|---|
| HGNC (Hugo) | SPO11 11250 |
| Cards |
|---|
| Entrez_Gene (NCBI) | SPO11 23626 SPO11 initiator of meiotic double stranded breaks |
| Aliases | CT35; SPATA43; TOPVIA |
| GeneCards (Weizmann) | SPO11 |
| Ensembl hg19 (Hinxton) | ENSG00000054796 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000054796 [Gene_View] ENSG00000054796 [Sequence] chr20:57329803-57343993 [Contig_View] SPO11 [Vega] |
| ICGC DataPortal | ENSG00000054796 |
| TCGA cBioPortal | SPO11 |
| AceView (NCBI) | SPO11 |
| Genatlas (Paris) | SPO11 |
| WikiGenes | 23626 |
| SOURCE (Princeton) | SPO11 |
| Genetics Home Reference (NIH) | SPO11 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | SPO11 - chr20:57329803-57343993 + 20q13.31 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | SPO11 - 20q13.31 [Description] (hg19-Feb_2009) |
| GoldenPath | SPO11 - 20q13.31 [CytoView hg19] SPO11 - 20q13.31 [CytoView hg38] |
| Genome Data Viewer NCBI | SPO11 [Mapview hg19] |
| OMIM | 605114 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF149310 AF169385 BC033591 |
| RefSeq transcript (Entrez) | NM_012444 NM_198265 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | SPO11 |
| Alternative Splicing Gallery | ENSG00000054796 |
| Gene Expression | SPO11 [ NCBI-GEO ] SPO11 [ EBI - ARRAY_EXPRESS ]
SPO11 [ SEEK ] SPO11 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | SPO11 [ Firebrowse - Broad ] |
| Genevisible | Expression of SPO11 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 23626 |
| GTEX Portal (Tissue expression) | SPO11 |
| Human Protein Atlas | ENSG00000054796-SPO11 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9Y5K1 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q9Y5K1 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q9Y5K1 |
| Splice isoforms : SwissVar | Q9Y5K1 |
| PhosPhoSitePlus | Q9Y5K1 |
| Domains : Interpro (EBI) | Meiosis_Spo11 Meiotic_Spo11 Spo11/TopoVI_A Spo11/TopoVI_A_N Spo11/TopoVI_A_sf TOPRIM_Topo6A/Spo11 WH-like_DNA-bd_sf |
| Domain families : Pfam (Sanger) | SPO11_like (PF03533) TP6A_N (PF04406) |
| Domain families : Pfam (NCBI) | pfam03533 pfam04406 |
| Conserved Domain (NCBI) | SPO11 |
| DMDM Disease mutations | 23626 |
| Superfamily | Q9Y5K1 |
| Human Protein Atlas [tissue] | ENSG00000054796-SPO11 [tissue] |
| Peptide Atlas | Q9Y5K1 |
| IPI | IPI00843905 IPI00181896 IPI00514616 IPI00641521 IPI00647244 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9Y5K1 |
| IntAct (EBI) | Q9Y5K1 |
| FunCoup | ENSG00000054796 |
| BioGRID | SPO11 |
| STRING (EMBL) | SPO11 |
| ZODIAC | SPO11 |
| Ontologies - Pathways |
|---|
| QuickGO | Q9Y5K1 |
| Ontology : AmiGO | nuclear chromosome meiotic DNA double-strand break processing DNA catabolic process, endonucleolytic chromosome, telomeric region ovarian follicle development DNA binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein binding ATP binding synaptonemal complex assembly reciprocal meiotic recombination male meiosis I spermatogenesis spermatid development female gamete generation endodeoxyribonuclease activity, producing 3'-phosphomonoesters protein localization to chromosome meiotic DNA double-strand break formation meiotic telomere clustering metal ion binding oogenesis double-strand break repair involved in meiotic recombination |
| Ontology : EGO-EBI | nuclear chromosome meiotic DNA double-strand break processing DNA catabolic process, endonucleolytic chromosome, telomeric region ovarian follicle development DNA binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein binding ATP binding synaptonemal complex assembly reciprocal meiotic recombination male meiosis I spermatogenesis spermatid development female gamete generation endodeoxyribonuclease activity, producing 3'-phosphomonoesters protein localization to chromosome meiotic DNA double-strand break formation meiotic telomere clustering metal ion binding oogenesis double-strand break repair involved in meiotic recombination |
| NDEx Network | SPO11 |
| Atlas of Cancer Signalling Network | SPO11 |
| Wikipedia pathways | SPO11 |
| Orthology - Evolution |
|---|
| OrthoDB | 23626 |
| GeneTree (enSembl) | ENSG00000054796 |
| Phylogenetic Trees/Animal Genes : TreeFam | SPO11 |
| HOGENOM | Q9Y5K1 |
| Homologs : HomoloGene | SPO11 |
| Homology/Alignments : Family Browser (UCSC) | SPO11 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | SPO11 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | SPO11 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | SPO11 |
| dbVar | SPO11 |
| ClinVar | SPO11 |
| 1000_Genomes | SPO11 |
| Exome Variant Server | SPO11 |
| GNOMAD Browser | ENSG00000054796 |
| Varsome Browser | SPO11 |
| Genetic variants : HAPMAP | 23626 |
| Genomic Variants (DGV) | SPO11 [DGVbeta] |
| DECIPHER | SPO11 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | SPO11 |
| Mutations |
|---|
| ICGC Data Portal | SPO11 |
| TCGA Data Portal | SPO11 |
| Broad Tumor Portal | SPO11 |
| OASIS Portal | SPO11 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | SPO11 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | SPO11 |
| Mutations and Diseases : HGMD | SPO11 |
| BioMuta | select SPO11 |
| DgiDB (Drug Gene Interaction Database) | SPO11 |
| DoCM (Curated mutations) | SPO11 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | SPO11 (select a term) |
| intoGen | SPO11 |
| Cancer3D | SPO11 (select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 605114 |
| Orphanet | |
| DisGeNET | SPO11 |
| Medgen | SPO11 |
| Genetic Testing Registry | SPO11
|
| NextProt | Q9Y5K1 [Medical] |
| TSGene | 23626 |
| GENETests | SPO11 |
| Open Targets Genetics | ENSG00000054796 [validation] |
| snp3D : Map Gene to Disease | 23626 |
| BioCentury BCIQ | SPO11 |
| ClinGen | SPO11 |
| Clinical trials, drugs, therapy |
|---|
| Protein Interactions : CTD | 23626 |
| Pharm GKB Gene | PA36080 |
| Clinical trial | SPO11 |
| Miscellaneous |
|---|
| canSAR (ICR) | SPO11 (select the gene name) |
| Harmonizome | SPO11 |
| DataMed Index | SPO11 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 19 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | SPO11 |
| EVEX | SPO11 |
