| Nomenclature |
HGNC (Hugo) | SPO11 11250 |
| Cards |
Entrez_Gene (NCBI) | SPO11 23626 SPO11 initiator of meiotic double stranded breaks |
Aliases | CT35; SPATA43; TOPVIA |
GeneCards (Weizmann) | SPO11 |
Ensembl hg19 (Hinxton) | ENSG00000054796 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000054796 [Gene_View]  ENSG00000054796 [Sequence] chr20:57329775-57343993 [Contig_View] SPO11 [Vega] |
ICGC DataPortal | ENSG00000054796 |
TCGA cBioPortal | SPO11 |
AceView (NCBI) | SPO11 |
Genatlas (Paris) | SPO11 |
WikiGenes | 23626 |
SOURCE (Princeton) | SPO11 |
Genetics Home Reference (NIH) | SPO11 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | SPO11 - chr20:57329775-57343993 + 20q13.31 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | SPO11 - 20q13.31 [Description] (hg19-Feb_2009) |
GoldenPath | SPO11 - 20q13.31 [CytoView hg19] SPO11 - 20q13.31 [CytoView hg38] |
ImmunoBase | ENSG00000054796 |
Mapping of homologs : NCBI | SPO11 [Mapview hg19] SPO11 [Mapview hg38] |
OMIM | 605114 |
| Gene and transcription |
Genbank (Entrez) | AF149310 AF169385 BC033591 |
RefSeq transcript (Entrez) | NM_012444 NM_198265 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | SPO11 |
Cluster EST : Unigene | Hs.159737 [ NCBI ] |
CGAP (NCI) | Hs.159737 |
Alternative Splicing Gallery | ENSG00000054796 |
Gene Expression | SPO11 [ NCBI-GEO ] SPO11 [ EBI - ARRAY_EXPRESS ]
SPO11 [ SEEK ] SPO11 [ MEM ] |
Gene Expression Viewer (FireBrowse) | SPO11 [ Firebrowse - Broad ] |
SOURCE (Princeton) | Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60] |
Genevestigator | Expression in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 23626 |
GTEX Portal (Tissue expression) | SPO11 |
Human Protein Atlas | ENSG00000054796-SPO11 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | Q9Y5K1 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | Q9Y5K1 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | Q9Y5K1 |
Splice isoforms : SwissVar | Q9Y5K1 |
PhosPhoSitePlus | Q9Y5K1 |
Domains : Interpro (EBI) | Meiosis_Spo11 Meiotic_Spo11 Spo11/TopoVI_A Spo11/TopoVI_A_N Spo11/TopoVI_A_sf TOPRIM_Topo6A/Spo11 WH-like_DNA-bd_sf |
Domain families : Pfam (Sanger) | SPO11_like (PF03533) TP6A_N (PF04406) |
Domain families : Pfam (NCBI) | pfam03533 pfam04406 |
Conserved Domain (NCBI) | SPO11 |
DMDM Disease mutations | 23626 |
Blocks (Seattle) | SPO11 |
Superfamily | Q9Y5K1 |
Human Protein Atlas [tissue] | ENSG00000054796-SPO11 [tissue] |
Peptide Atlas | Q9Y5K1 |
IPI | IPI00843905 IPI00181896 IPI00514616 IPI00641521 IPI00647244 |
| Protein Interaction databases |
DIP (DOE-UCLA) | Q9Y5K1 |
IntAct (EBI) | Q9Y5K1 |
FunCoup | ENSG00000054796 |
BioGRID | SPO11 |
STRING (EMBL) | SPO11 |
ZODIAC | SPO11 |
| Ontologies - Pathways |
QuickGO | Q9Y5K1 |
Ontology : AmiGO | meiotic DNA double-strand break processing DNA catabolic process, endonucleolytic chromosome, telomeric region ovarian follicle development DNA binding protein binding ATP binding nucleus synaptonemal complex assembly reciprocal meiotic recombination male meiosis I spermatogenesis spermatid development female gamete generation isomerase activity endodeoxyribonuclease activity, producing 3'-phosphomonoesters protein localization to chromosome meiotic DNA double-strand break formation meiotic telomere clustering metal ion binding oogenesis double-strand break repair involved in meiotic recombination |
Ontology : EGO-EBI | meiotic DNA double-strand break processing DNA catabolic process, endonucleolytic chromosome, telomeric region ovarian follicle development DNA binding protein binding ATP binding nucleus synaptonemal complex assembly reciprocal meiotic recombination male meiosis I spermatogenesis spermatid development female gamete generation isomerase activity endodeoxyribonuclease activity, producing 3'-phosphomonoesters protein localization to chromosome meiotic DNA double-strand break formation meiotic telomere clustering metal ion binding oogenesis double-strand break repair involved in meiotic recombination |
NDEx Network | SPO11 |
Atlas of Cancer Signalling Network | SPO11 |
Wikipedia pathways | SPO11 |
| Orthology - Evolution |
OrthoDB | 23626 |
GeneTree (enSembl) | ENSG00000054796 |
Phylogenetic Trees/Animal Genes : TreeFam | SPO11 |
HOGENOM | Q9Y5K1 |
Homologs : HomoloGene | SPO11 |
Homology/Alignments : Family Browser (UCSC) | SPO11 |
| Gene fusions - Rearrangements |
Fusion : Quiver | SPO11 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | SPO11 [hg38] |
dbSNP Single Nucleotide Polymorphism (NCBI) | SPO11 |
dbVar | SPO11 |
ClinVar | SPO11 |
1000_Genomes | SPO11 |
Exome Variant Server | SPO11 |
ExAC (Exome Aggregation Consortium) | ENSG00000054796 |
GNOMAD Browser | ENSG00000054796 |
Varsome Browser | SPO11 |
Genetic variants : HAPMAP | 23626 |
Genomic Variants (DGV) | SPO11 [DGVbeta] |
DECIPHER | SPO11 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | SPO11 |
| Mutations |
ICGC Data Portal | SPO11 |
TCGA Data Portal | SPO11 |
Broad Tumor Portal | SPO11 |
OASIS Portal | SPO11 [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | SPO11 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | SPO11 |
Mutations and Diseases : HGMD | SPO11 |
BioMuta | search SPO11 |
DgiDB (Drug Gene Interaction Database) | SPO11 |
DoCM (Curated mutations) | SPO11 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | SPO11 (select a term) |
intoGen | SPO11 |
Cancer3D | SPO11(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
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OMIM | 605114 |
Orphanet | |
DisGeNET | SPO11 |
Medgen | SPO11 |
Genetic Testing Registry | SPO11
|
NextProt | Q9Y5K1 [Medical] |
TSGene | 23626 |
GENETests | SPO11 |
Target Validation | SPO11 |
Huge Navigator |
SPO11 [HugePedia] |
snp3D : Map Gene to Disease | 23626 |
BioCentury BCIQ | SPO11 |
ClinGen | SPO11 |
| Clinical trials, drugs, therapy |
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Chemical/Protein Interactions : CTD | 23626 |
Chemical/Pharm GKB Gene | PA36080 |
Clinical trial | SPO11 |
| Miscellaneous |
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canSAR (ICR) | SPO11 (select the gene name) |
DataMed Index | SPO11 |
| Probes |
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| Litterature |
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PubMed | 18 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
CoreMine | SPO11 |
EVEX | SPO11 |
GoPubMed | SPO11 |
iHOP | SPO11 |