SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1)

2003-11-01  

Identity

HGNC
SPOCK1
LOCATION
5q31.2
LOCUSID
6695
ALIAS
SPOCK,TESTICAN,TIC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6695
MIM: 602264
HGNC: 11251
Ensembl: ENSG00000152377

Variants:

dbSNP: 6695
ClinVar: 6695
TCGA: ENSG00000152377
COSMIC: SPOCK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152377ENST00000282223A0A0A0MQX7
ENSG00000152377ENST00000394945Q08629
ENSG00000152377ENST00000505690D6RB21
ENSG00000152377ENST00000510689D6RAM7

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
238730222014Testican-1-mediated epithelial-mesenchymal transition signaling confers acquired resistance to lapatinib in HER2-positive gastric cancer.44
256230552015SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway.40
192829852009Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche.35
192829852009Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche.35
230224952013SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in mice.31
241348452013SPOCK1 is a novel transforming growth factor-β target gene that regulates lung cancer cell epithelial-mesenchymal transition.25
289406392018SPOCK1 promotes the invasion and metastasis of gastric cancer through Slug-induced epithelial-mesenchymal transition.19
165962172006Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater.14
292337212018Antitumor miR-150-5p and miR-150-3p inhibit cancer cell aggressiveness by targeting SPOCK1 in head and neck squamous cell carcinoma.14

Citation

Dessen P

SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42376/spock1