Identity
HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
IMP-4,IMP4,PSH4,PSL1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 56928
MIM: 608239
HGNC: 30627
Ensembl: ENSG00000005206
Variants:
dbSNP: 56928
ClinVar: 56928
TCGA: ENSG00000005206
COSMIC: SPPL2B
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Death Receptor Signalling | REACTOME | R-HSA-73887 |
| TNF signaling | REACTOME | R-HSA-75893 |
| Regulation of TNFR1 signaling | REACTOME | R-HSA-5357905 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38367747 | 2024 | Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease. | 0 |
| 38367747 | 2024 | Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease. | 0 |
| 30819724 | 2019 | Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis. | 17 |
| 30819724 | 2019 | Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis. | 17 |
| 23384347 | 2013 | The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b. | 10 |
| 23384347 | 2013 | The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b. | 10 |
| 22194595 | 2012 | The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). | 20 |
| 22194595 | 2012 | The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). | 20 |
| 17965014 | 2008 | Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. | 76 |
| 18768471 | 2008 | Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. | 15 |
| 17965014 | 2008 | Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. | 76 |
| 18768471 | 2008 | Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. | 15 |
| 16829951 | 2006 | A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. | 65 |
| 16829951 | 2006 | A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. | 65 |
| 15998642 | 2005 | Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. | 37 |
Citation
Dessen P
SPPL2B (signal peptide peptidase like 2B)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46149/sppl2b
