SPRR1A (small proline rich protein 1A)

2015-03-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
SPRK
FUSION GENES

Other Information

Locus ID:

NCBI: 6698
MIM: 182265
HGNC: 11259
Ensembl: ENSG00000169474

Variants:

dbSNP: 6698
ClinVar: 6698
TCGA: ENSG00000169474
COSMIC: SPRR1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169474ENST00000368762P35321

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186438452009Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.16
196720942010Locus 1q21 Gene expression changes in atopic dermatitis skin lesions: deregulation of small proline-rich region 1A.7
273040822017Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.6
196019982009Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.3
248860192014Clinical implications of SPRR1A expression in diffuse large B-cell lymphomas: a prospective, observational study.2
254247022015Clinical significance of SPRR1A expression in progesterone receptor-positive breast cancer.2

Citation

Dessen P

SPRR1A (small proline rich protein 1A)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55116/sprr1a