SPRR3 (small proline rich protein 3)

2008-01-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 6707
MIM: 182271
HGNC: 11268
Ensembl: ENSG00000163209

Variants:

dbSNP: 6707
ClinVar: 6707
TCGA: ENSG00000163209
COSMIC: SPRR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163209ENST00000295367Q9UBC9
ENSG00000163209ENST00000331860Q9UBC9
ENSG00000163209ENST00000443178B1AN48

Expression (GTEx)

0
5000
10000
15000

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
214906202011Association screening in the Epidermal Differentiation Complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema.20
186438452009Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.16
152219702004Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression.15
203796132010Upregulation of SPRR3 promotes colorectal tumorigenesis.13
220764812012Expression of SPRR3 is associated with tumor cell proliferation in less advanced stages of breast cancer.12
179351332008Exogenous expression of Esophagin/SPRR3 attenuates the tumorigenicity of esophageal squamous cell carcinoma cells via promoting apoptosis.10
188325732008Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction.10
192112702010Biomechanical stress induces novel arterial intima-enriched genes: implications for vascular adaptation to stress.8
217775802011Quantitative evaluation of SPRR3 expression in esophageal squamous cell carcinoma by qPCR and its potential use as a biomarker.6
273040822017Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.6

Citation

Dessen P

SPRR3 (small proline rich protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/50003/sprr3