Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SPRY2 (sprouty RTK signaling antagonist 2)

Identity

Alias (NCBI)IGAN3
hSPRY2
HGNC (Hugo) SPRY2
HGNC Alias symbhSPRY2
HGNC Previous namesprouty (Drosophila) homolog 2
 sprouty homolog 2 (Drosophila)
LocusID (NCBI) 10253
Atlas_Id 42381
Location 13q31.1  [Link to chromosome band 13q31]
Location_base_pair Starts at 80335977 and ends at 80341126 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYP20A1 (2q33.2) / SPRY2 (13q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SPRY2   11270
Cards
Entrez_Gene (NCBI)SPRY2    sprouty RTK signaling antagonist 2
AliasesIGAN3; hSPRY2
GeneCards (Weizmann)SPRY2
Ensembl hg19 (Hinxton)ENSG00000136158 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136158 [Gene_View]  ENSG00000136158 [Sequence]  chr13:80335977-80341126 [Contig_View]  SPRY2 [Vega]
ICGC DataPortalENSG00000136158
TCGA cBioPortalSPRY2
AceView (NCBI)SPRY2
Genatlas (Paris)SPRY2
SOURCE (Princeton)SPRY2
Genetics Home Reference (NIH)SPRY2
Genomic and cartography
GoldenPath hg38 (UCSC)SPRY2  -     chr13:80335977-80341126 -  13q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPRY2  -     13q31.1   [Description]    (hg19-Feb_2009)
GoldenPathSPRY2 - 13q31.1 [CytoView hg19]  SPRY2 - 13q31.1 [CytoView hg38]
ImmunoBaseENSG00000136158
genome Data Viewer NCBISPRY2 [Mapview hg19]  
OMIM602466   616818   
Gene and transcription
Genbank (Entrez)AF039843 AK313810 AL713749 BC004205 BC015745
RefSeq transcript (Entrez)NM_001318536 NM_001318537 NM_001318538 NM_005842
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPRY2
Alternative Splicing GalleryENSG00000136158
Gene ExpressionSPRY2 [ NCBI-GEO ]   SPRY2 [ EBI - ARRAY_EXPRESS ]   SPRY2 [ SEEK ]   SPRY2 [ MEM ]
Gene Expression Viewer (FireBrowse)SPRY2 [ Firebrowse - Broad ]
GenevisibleExpression of SPRY2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10253
GTEX Portal (Tissue expression)SPRY2
Human Protein AtlasENSG00000136158-SPRY2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43597   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43597  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43597
Splice isoforms : SwissVarO43597
PhosPhoSitePlusO43597
Domaine pattern : Prosite (Expaxy)SPR (PS51227)   
Domains : Interpro (EBI)Sprouty    SPRY2   
Domain families : Pfam (Sanger)Sprouty (PF05210)   
Domain families : Pfam (NCBI)pfam05210   
Conserved Domain (NCBI)SPRY2
Blocks (Seattle)SPRY2
PDB (RSDB)3BUM    3OB1    5HKY    5HKZ    5HL0   
PDB Europe3BUM    3OB1    5HKY    5HKZ    5HL0   
PDB (PDBSum)3BUM    3OB1    5HKY    5HKZ    5HL0   
PDB (IMB)3BUM    3OB1    5HKY    5HKZ    5HL0   
Structural Biology KnowledgeBase3BUM    3OB1    5HKY    5HKZ    5HL0   
SCOP (Structural Classification of Proteins)3BUM    3OB1    5HKY    5HKZ    5HL0   
CATH (Classification of proteins structures)3BUM    3OB1    5HKY    5HKZ    5HL0   
SuperfamilyO43597
Human Protein Atlas [tissue]ENSG00000136158-SPRY2 [tissue]
Peptide AtlasO43597
HPRD03916
IPIIPI01014320   IPI00012913   
Protein Interaction databases
DIP (DOE-UCLA)O43597
IntAct (EBI)O43597
BioGRIDSPRY2
STRING (EMBL)SPRY2
ZODIACSPRY2
Ontologies - Pathways
QuickGOO43597
Ontology : AmiGOestablishment of mitotic spindle orientation  protein binding  nucleus  cytosol  cytosol  cytosol  cytoskeleton  plasma membrane  sensory perception of sound  negative regulation of cell proliferation  positive regulation of gene expression  negative regulation of epithelial to mesenchymal transition  negative regulation of peptidyl-threonine phosphorylation  actin cytoskeleton  microtubule cytoskeleton  membrane  negative regulation of angiogenesis  protein kinase binding  protein serine/threonine kinase inhibitor activity  positive regulation of cell migration  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of cell projection organization  ruffle membrane  positive regulation of peptidyl-serine phosphorylation  negative regulation of GTPase activity  cellular response to vascular endothelial growth factor stimulus  negative regulation of fibroblast growth factor receptor signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  inner ear morphogenesis  negative regulation of apoptotic process  negative regulation of MAP kinase activity  protein serine/threonine kinase activator activity  cell fate commitment  negative regulation of Ras protein signal transduction  animal organ development  negative regulation of neurotrophin TRK receptor signaling pathway  positive regulation of protein kinase B signaling  lung growth  bud elongation involved in lung branching  negative regulation of ERK1 and ERK2 cascade  negative regulation of ERK1 and ERK2 cascade  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of protein serine/threonine kinase activity  negative regulation of vascular endothelial growth factor signaling pathway  negative regulation of lens fiber cell differentiation  microtubule end  cellular response to leukemia inhibitory factor  
Ontology : EGO-EBIestablishment of mitotic spindle orientation  protein binding  nucleus  cytosol  cytosol  cytosol  cytoskeleton  plasma membrane  sensory perception of sound  negative regulation of cell proliferation  positive regulation of gene expression  negative regulation of epithelial to mesenchymal transition  negative regulation of peptidyl-threonine phosphorylation  actin cytoskeleton  microtubule cytoskeleton  membrane  negative regulation of angiogenesis  protein kinase binding  protein serine/threonine kinase inhibitor activity  positive regulation of cell migration  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of cell projection organization  ruffle membrane  positive regulation of peptidyl-serine phosphorylation  negative regulation of GTPase activity  cellular response to vascular endothelial growth factor stimulus  negative regulation of fibroblast growth factor receptor signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  inner ear morphogenesis  negative regulation of apoptotic process  negative regulation of MAP kinase activity  protein serine/threonine kinase activator activity  cell fate commitment  negative regulation of Ras protein signal transduction  animal organ development  negative regulation of neurotrophin TRK receptor signaling pathway  positive regulation of protein kinase B signaling  lung growth  bud elongation involved in lung branching  negative regulation of ERK1 and ERK2 cascade  negative regulation of ERK1 and ERK2 cascade  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of protein serine/threonine kinase activity  negative regulation of vascular endothelial growth factor signaling pathway  negative regulation of lens fiber cell differentiation  microtubule end  cellular response to leukemia inhibitory factor  
Pathways : KEGGJak-STAT signaling pathway    MicroRNAs in cancer   
NDEx NetworkSPRY2
Atlas of Cancer Signalling NetworkSPRY2
Wikipedia pathwaysSPRY2
Orthology - Evolution
OrthoDB10253
GeneTree (enSembl)ENSG00000136158
Phylogenetic Trees/Animal Genes : TreeFamSPRY2
HOGENOMO43597
Homologs : HomoloGeneSPRY2
Homology/Alignments : Family Browser (UCSC)SPRY2
Gene fusions - Rearrangements
Fusion : QuiverSPRY2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPRY2 [hg38]
dbVarSPRY2
ClinVarSPRY2
MonarchSPRY2
1000_GenomesSPRY2 
Exome Variant ServerSPRY2
GNOMAD BrowserENSG00000136158
Varsome BrowserSPRY2
Genomic Variants (DGV)SPRY2 [DGVbeta]
DECIPHERSPRY2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPRY2 
Mutations
ICGC Data PortalSPRY2 
TCGA Data PortalSPRY2 
Broad Tumor PortalSPRY2
OASIS PortalSPRY2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPRY2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSPRY2
Mutations and Diseases : HGMDSPRY2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPRY2
DgiDB (Drug Gene Interaction Database)SPRY2
DoCM (Curated mutations)SPRY2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPRY2 (select a term)
intoGenSPRY2
Cancer3DSPRY2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602466    616818   
Orphanet
DisGeNETSPRY2
MedgenSPRY2
Genetic Testing Registry SPRY2
NextProtO43597 [Medical]
GENETestsSPRY2
Target ValidationSPRY2
Huge Navigator SPRY2 [HugePedia]
ClinGenSPRY2
Clinical trials, drugs, therapy
MyCancerGenomeSPRY2
Protein Interactions : CTD
Pharm GKB GenePA36099
PharosO43597
Clinical trialSPRY2
Miscellaneous
canSAR (ICR)SPRY2 (select the gene name)
HarmonizomeSPRY2
DataMed IndexSPRY2
Probes
Litterature
PubMed196 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSPRY2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:39:07 CET 2021
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