SPRY4 (sprouty RTK signaling antagonist 4)

2007-02-01  

Identity

HGNC
LOCATION
5q31.3
LOCUSID
ALIAS
HH17
FUSION GENES

Other Information

Locus ID:

NCBI: 81848
MIM: 607984
HGNC: 15533
Ensembl: ENSG00000187678

Variants:

dbSNP: 81848
ClinVar: 81848
TCGA: ENSG00000187678
COSMIC: SPRY4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187678ENST00000344120A0A0C4DFS6
ENSG00000187678ENST00000434127Q9C004
ENSG00000187678ENST00000511815D6RB56

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194836822009Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.132
194836822009Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.132
279564982017H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal squamous cell carcinoma.72
127174432003Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.71
253448592014The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells.62
257429522015The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression.57
248109252014Long noncoding RNA SPRY4-IT1 is upregulated in esophageal squamous cell carcinoma and associated with poor prognosis.50
262860242015The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma.38
205016432010Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer.34
163885052006Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer.29

Citation

Dessen P

SPRY4 (sprouty RTK signaling antagonist 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43800/spry4