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SRCIN1 (SRC kinase signaling inhibitor 1)

Identity

Other namesP140
SNIP
HGNC (Hugo) SRCIN1
LocusID (NCBI) 80725
Atlas_Id 49749
Location 17q12
Location_base_pair Starts at 36686259 and ends at 36762183 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACACA (17q12) / SRCIN1 (17q12)SOCS7 (17q12) / SRCIN1 (17q12)SRCIN1 (17q12) / ARNT2 (15q25.1)
SRCIN1 (17q12) / PCYT2 (17q25.3)ACACA 17q12 / SRCIN1 17q12SOCS7 17q12 / SRCIN1 17q12
SRCIN1 17q12 / PCYT2 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SRCIN1   29506
Cards
Entrez_Gene (NCBI)SRCIN1  80725  SRC kinase signaling inhibitor 1
GeneCards (Weizmann)SRCIN1
Ensembl hg19 (Hinxton)ENSG00000277363 [Gene_View]  chr17:36686259-36762183 [Contig_View]  SRCIN1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000277363 [Gene_View]  chr17:36686259-36762183 [Contig_View]  SRCIN1 [Vega]
ICGC DataPortalENSG00000277363
TCGA cBioPortalSRCIN1
AceView (NCBI)SRCIN1
Genatlas (Paris)SRCIN1
WikiGenes80725
SOURCE (Princeton)SRCIN1
Genomic and cartography
GoldenPath hg19 (UCSC)SRCIN1  -     chr17:36686259-36762183 -  17q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SRCIN1  -     17q12   [Description]    (hg38-Dec_2013)
EnsemblSRCIN1 - 17q12 [CytoView hg19]  SRCIN1 - 17q12 [CytoView hg38]
Mapping of homologs : NCBISRCIN1 [Mapview hg19]  SRCIN1 [Mapview hg38]
OMIM610786   
Gene and transcription
Genbank (Entrez)AB051471 AB127405 AK096097 AK126665 AK126676
RefSeq transcript (Entrez)NM_025248
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NT_187614 NW_004929407
Consensus coding sequences : CCDS (NCBI)SRCIN1
Cluster EST : UnigeneHs.448872 [ NCBI ]
CGAP (NCI)Hs.448872
Alternative Splicing GalleryENSG00000277363
Gene ExpressionSRCIN1 [ NCBI-GEO ]   SRCIN1 [ EBI - ARRAY_EXPRESS ]   SRCIN1 [ SEEK ]   SRCIN1 [ MEM ]
Gene Expression Viewer (FireBrowse)SRCIN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80725
GTEX Portal (Tissue expression)SRCIN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C0H9 (Uniprot)
NextProtQ9C0H9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C0H9
Splice isoforms : SwissVarQ9C0H9 (Swissvar)
PhosPhoSitePlusQ9C0H9
Domains : Interpro (EBI)AIP3_C    Srcin1   
Domain families : Pfam (Sanger)AIP3 (PF03915)   
Domain families : Pfam (NCBI)pfam03915   
DMDM Disease mutations80725
Blocks (Seattle)SRCIN1
SuperfamilyQ9C0H9
Human Protein AtlasENSG00000277363
Peptide AtlasQ9C0H9
HPRD11589
IPIIPI00479643   IPI00964306   IPI00384305   IPI00396130   IPI01013588   IPI00883713   
Protein Interaction databases
DIP (DOE-UCLA)Q9C0H9
IntAct (EBI)Q9C0H9
FunCoupENSG00000277363
BioGRIDSRCIN1
STRING (EMBL)SRCIN1
ZODIACSRCIN1
Ontologies - Pathways
QuickGOQ9C0H9
Ontology : AmiGOprotein binding  cytoplasm  focal adhesion  exocytosis  postsynaptic density  actin cytoskeleton  protein kinase binding  protein domain specific binding  lamellipodium  filopodium  regulation of cell migration  axon  dendrite  substrate adhesion-dependent cell spreading  neuronal cell body  synapse  postsynaptic membrane  negative regulation of protein secretion  regulation of dendritic spine morphogenesis  positive regulation of protein tyrosine kinase activity  negative regulation of protein tyrosine kinase activity  
Ontology : EGO-EBIprotein binding  cytoplasm  focal adhesion  exocytosis  postsynaptic density  actin cytoskeleton  protein kinase binding  protein domain specific binding  lamellipodium  filopodium  regulation of cell migration  axon  dendrite  substrate adhesion-dependent cell spreading  neuronal cell body  synapse  postsynaptic membrane  negative regulation of protein secretion  regulation of dendritic spine morphogenesis  positive regulation of protein tyrosine kinase activity  negative regulation of protein tyrosine kinase activity  
NDEx Network
Atlas of Cancer Signalling NetworkSRCIN1
Wikipedia pathwaysSRCIN1
Orthology - Evolution
OrthoDB80725
GeneTree (enSembl)ENSG00000277363
Phylogenetic Trees/Animal Genes : TreeFamSRCIN1
Homologs : HomoloGeneSRCIN1
Homology/Alignments : Family Browser (UCSC)SRCIN1
Gene fusions - Rearrangements
Fusion: TCGAACACA 17q12 SRCIN1 17q12 LUAD
Fusion: TCGASOCS7 17q12 SRCIN1 17q12 BRCA
Fusion: TCGASRCIN1 17q12 PCYT2 17q25.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerSRCIN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRCIN1
dbVarSRCIN1
ClinVarSRCIN1
1000_GenomesSRCIN1 
Exome Variant ServerSRCIN1
ExAC (Exome Aggregation Consortium)SRCIN1 (select the gene name)
Genetic variants : HAPMAP80725
Genomic Variants (DGV)SRCIN1 [DGVbeta]
Mutations
ICGC Data PortalSRCIN1 
TCGA Data PortalSRCIN1 
Broad Tumor PortalSRCIN1
OASIS PortalSRCIN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRCIN1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRCIN1
DgiDB (Drug Gene Interaction Database)SRCIN1
DoCM (Curated mutations)SRCIN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRCIN1 (select a term)
intoGenSRCIN1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:36686259-36762183  ENSG00000277363
CONAN: Copy Number AnalysisSRCIN1 
Mutations and Diseases : HGMDSRCIN1
OMIM610786   
MedgenSRCIN1
Genetic Testing Registry SRCIN1
NextProtQ9C0H9 [Medical]
TSGene80725
GENETestsSRCIN1
Huge Navigator SRCIN1 [HugePedia]
snp3D : Map Gene to Disease80725
BioCentury BCIQSRCIN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80725
Chemical/Pharm GKB GenePA165432823
Clinical trialSRCIN1
Miscellaneous
canSAR (ICR)SRCIN1 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRCIN1
EVEXSRCIN1
GoPubMedSRCIN1
iHOPSRCIN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 19:07:14 CEST 2016

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