SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1)

2006-10-01 Affiliation

Identity

HGNC

SRGAP1

LOCATION

12q14.2

LOCUSID

57522

ALIAS

ARHGAP13,NMTC2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 57522
MIM: 606523
HGNC: 17382
Ensembl: ENSG00000196935

Variants:

dbSNP: 57522
ClinVar: 57522
TCGA: ENSG00000196935
COSMIC: SRGAP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000196935	ENST00000355086	Q7Z6B7
ENSG00000196935	ENST00000543397	G5EA48
ENSG00000196935	ENST00000631006	G5EA48

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Axon guidance	KEGG	hsa04360
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
Rho GTPase cycle	REACTOME	R-HSA-194840
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Signaling by Robo receptor	REACTOME	R-HSA-376176
Inactivation of Cdc42 and Rac	REACTOME	R-HSA-428543

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
25150978	2014	An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration.	33
25134534	2014	Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.	31
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
21060114	2011	The corticofugal neuron-associated genes ROBO1, SRGAP1, and CTIP2 exhibit an anterior to posterior gradient of expression in early fetal human neocortex development.	23
23539728	2013	SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility.	17
26026792	2015	Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.	17
24006490	2013	srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity.	13
29234151	2018	SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis.	12
27923383	2016	srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer.	8
26026080	2015	MicroRNA-145 Promotes the Phenotype of Human Glioblastoma Cells Selected for Invasion.	7

Citation

Dessen P

SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43502/srgap1