Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3)

Identity

Alias_namesSRGAP2
SLIT-ROBO Rho GTPase activating protein 2
Alias_symbol (synonym)KIAA0411
MEGAP
WRP
ARHGAP14
Other alias
HGNC (Hugo) SRGAP3
LocusID (NCBI) 9901
Atlas_Id 53052
Location 3p25.3  [Link to chromosome band 3p25]
Location_base_pair Starts at 8980591 and ends at 9249685 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IRAK2 (3p25.3) / SRGAP3 (3p25.3)KAT6A (8p11.21) / SRGAP3 (3p25.3)MDM4 (1q32.1) / SRGAP3 (3p25.3)
RAF1 (3p25.2) / SRGAP3 (3p25.3)SRGAP3 (3p25.3) / ATP2B2 (3p25.3)SRGAP3 (3p25.3) / FAM83H (8q24.3)
SRGAP3 (3p25.3) / RAF1 (3p25.2)SRGAP3 3p25.3 / RAF1 3p25.2IRAK2 3p25.3 / SRGAP3 3p25.3
SRGAP3 3p25.3 / ATP2B2 3p25.3SRGAP3 3p25.3 / FAM83H 8q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  dup(3)(p25p25) SRGAP3/RAF1
IRAK2/SRGAP3 (3p25)
SRGAP3/ATP2B2 (3p25)
t(3;8)(p25;q24) SRGAP3/FAM83H

External links

Nomenclature
HGNC (Hugo)SRGAP3   19744
Cards
Entrez_Gene (NCBI)SRGAP3  9901  SLIT-ROBO Rho GTPase activating protein 3
AliasesARHGAP14; MEGAP; SRGAP2; WRP
GeneCards (Weizmann)SRGAP3
Ensembl hg19 (Hinxton)ENSG00000196220 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196220 [Gene_View]  ENSG00000196220 [Sequence]  chr3:8980591-9249685 [Contig_View]  SRGAP3 [Vega]
ICGC DataPortalENSG00000196220
TCGA cBioPortalSRGAP3
AceView (NCBI)SRGAP3
Genatlas (Paris)SRGAP3
WikiGenes9901
SOURCE (Princeton)SRGAP3
Genetics Home Reference (NIH)SRGAP3
Genomic and cartography
GoldenPath hg38 (UCSC)SRGAP3  -     chr3:8980591-9249685 -  3p25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRGAP3  -     3p25.3   [Description]    (hg19-Feb_2009)
GoldenPathSRGAP3 - 3p25.3 [CytoView hg19]  SRGAP3 - 3p25.3 [CytoView hg38]
ImmunoBaseENSG00000196220
Mapping of homologs : NCBISRGAP3 [Mapview hg19]  SRGAP3 [Mapview hg38]
OMIM606525   
Gene and transcription
Genbank (Entrez)AB007871 AB032982 AF427144 AF464189 AK054831
RefSeq transcript (Entrez)NM_001033116 NM_001033117 NM_014850
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRGAP3
Cluster EST : UnigeneHs.654743 [ NCBI ]
CGAP (NCI)Hs.654743
Alternative Splicing GalleryENSG00000196220
Gene ExpressionSRGAP3 [ NCBI-GEO ]   SRGAP3 [ EBI - ARRAY_EXPRESS ]   SRGAP3 [ SEEK ]   SRGAP3 [ MEM ]
Gene Expression Viewer (FireBrowse)SRGAP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9901
GTEX Portal (Tissue expression)SRGAP3
Human Protein AtlasENSG00000196220-SRGAP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43295   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43295  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43295
Splice isoforms : SwissVarO43295
PhosPhoSitePlusO43295
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)    RHOGAP (PS50238)    SH3 (PS50002)   
Domains : Interpro (EBI)AH/BAR_dom_sf    F_BAR    FCH_dom    Rho_GTPase_activation_prot    RhoGAP_dom    SH3-like_dom_sf    SH3_domain    srGAP1/2/3_SH3   
Domain families : Pfam (Sanger)FCH (PF00611)    RhoGAP (PF00620)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00611    pfam00620    pfam00018   
Domain families : Smart (EMBL)FCH (SM00055)  RhoGAP (SM00324)  SH3 (SM00326)  
Conserved Domain (NCBI)SRGAP3
DMDM Disease mutations9901
Blocks (Seattle)SRGAP3
SuperfamilyO43295
Human Protein Atlas [tissue]ENSG00000196220-SRGAP3 [tissue]
Peptide AtlasO43295
HPRD12108
IPIIPI00218087   IPI00412209   IPI00412210   IPI01019101   IPI00847462   
Protein Interaction databases
DIP (DOE-UCLA)O43295
IntAct (EBI)O43295
FunCoupENSG00000196220
BioGRIDSRGAP3
STRING (EMBL)SRGAP3
ZODIACSRGAP3
Ontologies - Pathways
QuickGOO43295
Ontology : AmiGOGTPase activator activity  protein binding  cytoplasm  cytosol  signal transduction  negative regulation of cell migration  positive regulation of GTPase activity  Rac GTPase binding  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIGTPase activator activity  protein binding  cytoplasm  cytosol  signal transduction  negative regulation of cell migration  positive regulation of GTPase activity  Rac GTPase binding  regulation of small GTPase mediated signal transduction  
Pathways : KEGGAxon guidance   
NDEx NetworkSRGAP3
Atlas of Cancer Signalling NetworkSRGAP3
Wikipedia pathwaysSRGAP3
Orthology - Evolution
OrthoDB9901
GeneTree (enSembl)ENSG00000196220
Phylogenetic Trees/Animal Genes : TreeFamSRGAP3
HOGENOMO43295
Homologs : HomoloGeneSRGAP3
Homology/Alignments : Family Browser (UCSC)SRGAP3
Gene fusions - Rearrangements
Fusion : MitelmanIRAK2/SRGAP3 [3p25.3/3p25.3]  [t(3;3)(p25;p25)]  
Fusion : MitelmanSRGAP3/ATP2B2 [3p25.3/3p25.3]  [t(3;3)(p25;p25)]  
Fusion : MitelmanSRGAP3/FAM83H [3p25.3/8q24.3]  [t(3;8)(p25;q24)]  
Fusion : MitelmanSRGAP3/RAF1 [3p25.3/3p25.2]  [dup(3)(p25p25)]  
Fusion PortalIRAK2 3p25.3 SRGAP3 3p25.3 HNSC
Fusion PortalSRGAP3 3p25.3 ATP2B2 3p25.3 HNSC
Fusion PortalSRGAP3 3p25.3 FAM83H 8q24.3 BLCA
Fusion : QuiverSRGAP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRGAP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRGAP3
dbVarSRGAP3
ClinVarSRGAP3
1000_GenomesSRGAP3 
Exome Variant ServerSRGAP3
ExAC (Exome Aggregation Consortium)ENSG00000196220
GNOMAD BrowserENSG00000196220
Varsome BrowserSRGAP3
Genetic variants : HAPMAP9901
Genomic Variants (DGV)SRGAP3 [DGVbeta]
DECIPHERSRGAP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRGAP3 
Mutations
ICGC Data PortalSRGAP3 
TCGA Data PortalSRGAP3 
Broad Tumor PortalSRGAP3
OASIS PortalSRGAP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRGAP3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSRGAP3
Mutations and Diseases : HGMDSRGAP3
intOGen PortalSRGAP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRGAP3
DgiDB (Drug Gene Interaction Database)SRGAP3
DoCM (Curated mutations)SRGAP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRGAP3 (select a term)
intoGenSRGAP3
Cancer3DSRGAP3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606525   
Orphanet19659   
DisGeNETSRGAP3
MedgenSRGAP3
Genetic Testing Registry SRGAP3
NextProtO43295 [Medical]
TSGene9901
GENETestsSRGAP3
Target ValidationSRGAP3
Huge Navigator SRGAP3 [HugePedia]
snp3D : Map Gene to Disease9901
BioCentury BCIQSRGAP3
ClinGenSRGAP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9901
Chemical/Pharm GKB GenePA134935463
Clinical trialSRGAP3
Miscellaneous
canSAR (ICR)SRGAP3 (select the gene name)
DataMed IndexSRGAP3
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRGAP3
EVEXSRGAP3
GoPubMedSRGAP3
iHOPSRGAP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:09:33 CET 2019
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