SRGN (serglycin)

2011-08-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
PPG,PRG,PRG1
FUSION GENES

Other Information

Locus ID:

NCBI: 5552
MIM: 177040
HGNC: 9361
Ensembl: ENSG00000122862

Variants:

dbSNP: 5552
ClinVar: 5552
TCGA: ENSG00000122862
COSMIC: SRGN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122862ENST00000242465P10124

Expression (GTEx)

0
500
1000
1500
2000
2500

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
212891312011Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis.57
168706192006Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro.28
123885392002Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.19
210758442011Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1.19
244030682014Serglycin proteoglycan is required for multiple myeloma cell adhesion, in vivo growth, and vascularization.19
278196722017Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner.19
239962422013Serglycin (SRGN) overexpression predicts poor prognosis in hepatocellular carcinoma patients.18
147392292004The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis.15
233878272013Cell-surface serglycin promotes adhesion of myeloma cells to collagen type I and affects the expression of matrix metalloproteinases.15
212680132011Serglycin inhibits the classical and lectin pathways of complement via its glycosaminoglycan chains: implications for multiple myeloma.13

Citation

Dessen P

SRGN (serglycin)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52326/srgn