SRMS (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites)

2006-10-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
C20orf148,PTK70,SRM,dJ697K14.1

Other Information

Locus ID:

NCBI: 6725
MIM: 617797
HGNC: 11298
Ensembl: ENSG00000125508

Variants:

dbSNP: 6725
ClinVar: 6725
TCGA: ENSG00000125508
COSMIC: SRMS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125508ENST00000217188Q9H3Y6

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersREACTOMER-HSA-983695
Signal TransductionREACTOMER-HSA-162582
Signaling by PTK6REACTOMER-HSA-8848021
PTK6 Down-RegulationREACTOMER-HSA-8849472

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
340774192021The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51.8
340774192021The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51.8
294969072018Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites (SRMS).11
294969072018Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites (SRMS).11
258970812015Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase.27
258970812015Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase.27
238220912013The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1.16
238220912013The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1.16

Citation

Dessen P

SRMS (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43504/srms