SRP14 (signal recognition particle 14)

2014-11-01  

Identity

HGNC
SRP14
LOCATION
15q15.1
LOCUSID
6727
ALIAS
ALURBP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6727
MIM: 600708
HGNC: 11299
Ensembl: ENSG00000140319

Variants:

dbSNP: 6727
ClinVar: 6727
TCGA: ENSG00000140319
COSMIC: SRP14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140319ENST00000267884P37108
ENSG00000140319ENST00000558720H0YLW0
ENSG00000140319ENST00000559081H0YLA2
ENSG00000140319ENST00000560773H0YLW0

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein exportKEGGko03060
Protein exportKEGGhsa03060
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Gene ExpressionREACTOMER-HSA-74160
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
184559852008SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites.51
203484482010Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein.13
256975032015Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits.7

Citation

Dessen P

SRP14 (signal recognition particle 14)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74236/srp14