SRP19 (signal recognition particle 19)

2016-12-01  

Identity

HGNC
SRP19
LOCATION
5q22.2
LOCUSID
6728
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6728
MIM: 182175
HGNC: 11300
Ensembl: ENSG00000153037

Variants:

dbSNP: 6728
ClinVar: 6728
TCGA: ENSG00000153037
COSMIC: SRP19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153037ENST00000282999P09132
ENSG00000153037ENST00000391338A0A2U3TZN1
ENSG00000153037ENST00000445150A0A087WWU9
ENSG00000153037ENST00000503445A0A2R8Y4M3
ENSG00000153037ENST00000505459P09132
ENSG00000153037ENST00000506997D6RBG4
ENSG00000153037ENST00000515463P09132
ENSG00000153037ENST00000621420A0A087WYR0

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein exportKEGGko03060
Protein exportKEGGhsa03060
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD22795047
PA449015citalopramChemicalClinicalAnnotationassociatedPD22795047
PA449673fluoxetineChemicalClinicalAnnotationassociatedPD22795047
PA450801paroxetineChemicalClinicalAnnotationassociatedPD22795047
PA451333sertralineChemicalClinicalAnnotationassociatedPD22795047

References

Pubmed IDYearTitleCitations
120506742002Structure of the SRP19 RNA complex and implications for signal recognition particle assembly.41
122442992002Induced structural changes of 7SL RNA during the assembly of human signal recognition particle.35
116414992001Crystal structure of an early protein-RNA assembly complex of the signal recognition particle.25
174345352007A threefold RNA-protein interface in the signal recognition particle gates native complex assembly.8
201793412010Structural insights into the assembly of the human and archaeal signal recognition particles.7
278996662017Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.7
275259442016Expression of anti-SRP19 antibody in muscle tissues from patients with autoimmune necrotizing myopathy.2

Citation

Dessen P

SRP19 (signal recognition particle 19)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56668/srp19