SRP68 (signal recognition particle 68)

2014-05-01  

Identity

HGNC
SRP68
LOCATION
17q25.1
LOCUSID
6730
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6730
MIM: 604858
HGNC: 11302
Ensembl: ENSG00000167881

Variants:

dbSNP: 6730
ClinVar: 6730
TCGA: ENSG00000167881
COSMIC: SRP68

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167881ENST00000307877Q9UHB9
ENSG00000167881ENST00000539137Q9UHB9
ENSG00000167881ENST00000591272K7EQC2
ENSG00000167881ENST00000592704K7EN53
ENSG00000167881ENST00000602720Q9UHB9
ENSG00000167881ENST00000629930K7EN53

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein exportKEGGko03060
Protein exportKEGGhsa03060
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
247008612014SRP RNA remodeling by SRP68 explains its role in protein translocation.16
166722322006Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains.9
278996662017Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.7
230480282012A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.6
283695292017Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.2
306494172019Reconstitution of the human SRP system and quantitative and systematic analysis of its ribosome interactions.1

Citation

Dessen P

SRP68 (signal recognition particle 68)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53892/srp68