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SRPRA (SRP receptor subunit alpha)

Identity

Alias_namesSRPR
signal recognition particle receptor (docking protein)
Alias_symbol (synonym)SRP-alpha
Sralpha
SR-alpha
Other aliasDP
HGNC (Hugo) SRPRA
LocusID (NCBI) 6734
Atlas_Id 78019
Location 11q24.2  [Link to chromosome band 11q24]
Location_base_pair Starts at 126262919 and ends at 126268982 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SNHG1 (11q12.3) / SRPRA (11q24.2)SRPRA (11q24.2) / SRPRA (11q24.2)USH1C (11p15.1) / SRPRA (11q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SRPRA   11307
Cards
Entrez_Gene (NCBI)SRPRA  6734  SRP receptor subunit alpha
AliasesDP; SRPR; Sralpha
GeneCards (Weizmann)SRPRA
Ensembl hg19 (Hinxton)ENSG00000182934 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182934 [Gene_View]  ENSG00000182934 [Sequence]  chr11:126262919-126268982 [Contig_View]  SRPRA [Vega]
ICGC DataPortalENSG00000182934
TCGA cBioPortalSRPRA
AceView (NCBI)SRPRA
Genatlas (Paris)SRPRA
WikiGenes6734
SOURCE (Princeton)SRPRA
Genetics Home Reference (NIH)SRPRA
Genomic and cartography
GoldenPath hg38 (UCSC)SRPRA  -     chr11:126262919-126268982 -  11q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRPRA  -     11q24.2   [Description]    (hg19-Feb_2009)
GoldenPathSRPRA - 11q24.2 [CytoView hg19]  SRPRA - 11q24.2 [CytoView hg38]
ImmunoBaseENSG00000182934
Mapping of homologs : NCBISRPRA [Mapview hg19]  SRPRA [Mapview hg38]
OMIM182180   
Gene and transcription
Genbank (Entrez)AI422194 AK130382 AK303379 AK312377 BC001162
RefSeq transcript (Entrez)NM_001177842 NM_003139
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRPRA
Cluster EST : UnigeneHs.368376 [ NCBI ]
CGAP (NCI)Hs.368376
Alternative Splicing GalleryENSG00000182934
Gene ExpressionSRPRA [ NCBI-GEO ]   SRPRA [ EBI - ARRAY_EXPRESS ]   SRPRA [ SEEK ]   SRPRA [ MEM ]
Gene Expression Viewer (FireBrowse)SRPRA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6734
GTEX Portal (Tissue expression)SRPRA
Human Protein AtlasENSG00000182934-SRPRA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08240   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08240  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08240
Splice isoforms : SwissVarP08240
PhosPhoSitePlusP08240
Domaine pattern : Prosite (Expaxy)SRP54 (PS00300)   
Domains : Interpro (EBI)AAA+_ATPase    Longin-like_dom_sf    P-loop_NTPase    Sig_recog_particle_rcpt_asu_N    Signal_recog_particl_SRP54_hlx    SRP/SRP_N    SRP54_GTPase_dom   
Domain families : Pfam (Sanger)SRP-alpha_N (PF04086)    SRP54 (PF00448)    SRP54_N (PF02881)   
Domain families : Pfam (NCBI)pfam04086    pfam00448    pfam02881   
Domain families : Smart (EMBL)AAA (SM00382)  SRP54 (SM00962)  SRP54_N (SM00963)  
Conserved Domain (NCBI)SRPRA
DMDM Disease mutations6734
Blocks (Seattle)SRPRA
PDB (RSDB)2FH5    2GO5    5L3Q   
PDB Europe2FH5    2GO5    5L3Q   
PDB (PDBSum)2FH5    2GO5    5L3Q   
PDB (IMB)2FH5    2GO5    5L3Q   
Structural Biology KnowledgeBase2FH5    2GO5    5L3Q   
SCOP (Structural Classification of Proteins)2FH5    2GO5    5L3Q   
CATH (Classification of proteins structures)2FH5    2GO5    5L3Q   
SuperfamilyP08240
Human Protein Atlas [tissue]ENSG00000182934-SRPRA [tissue]
Peptide AtlasP08240
HPRD01645
IPIIPI00385267   IPI00964088   
Protein Interaction databases
DIP (DOE-UCLA)P08240
IntAct (EBI)P08240
FunCoupENSG00000182934
BioGRIDSRPRA
STRING (EMBL)SRPRA
ZODIACSRPRA
Ontologies - Pathways
QuickGOP08240
Ontology : AmiGORNA binding  GTPase activity  signal recognition particle binding  GTP binding  signal recognition particle receptor complex  endoplasmic reticulum membrane  endoplasmic reticulum membrane  protein targeting  cotranslational protein targeting to membrane  SRP-dependent cotranslational protein targeting to membrane  membrane  membrane  IRE1-mediated unfolded protein response  protein targeting to ER  extracellular exosome  
Ontology : EGO-EBIRNA binding  GTPase activity  signal recognition particle binding  GTP binding  signal recognition particle receptor complex  endoplasmic reticulum membrane  endoplasmic reticulum membrane  protein targeting  cotranslational protein targeting to membrane  SRP-dependent cotranslational protein targeting to membrane  membrane  membrane  IRE1-mediated unfolded protein response  protein targeting to ER  extracellular exosome  
NDEx NetworkSRPRA
Atlas of Cancer Signalling NetworkSRPRA
Wikipedia pathwaysSRPRA
Orthology - Evolution
OrthoDB6734
GeneTree (enSembl)ENSG00000182934
Phylogenetic Trees/Animal Genes : TreeFamSRPRA
HOGENOMP08240
Homologs : HomoloGeneSRPRA
Homology/Alignments : Family Browser (UCSC)SRPRA
Gene fusions - Rearrangements
Fusion : QuiverSRPRA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRPRA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRPRA
dbVarSRPRA
ClinVarSRPRA
1000_GenomesSRPRA 
Exome Variant ServerSRPRA
ExAC (Exome Aggregation Consortium)ENSG00000182934
GNOMAD BrowserENSG00000182934
Varsome BrowserSRPRA
Genetic variants : HAPMAP6734
Genomic Variants (DGV)SRPRA [DGVbeta]
DECIPHERSRPRA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRPRA 
Mutations
ICGC Data PortalSRPRA 
TCGA Data PortalSRPRA 
Broad Tumor PortalSRPRA
OASIS PortalSRPRA [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSRPRA
BioMutasearch SRPRA
DgiDB (Drug Gene Interaction Database)SRPRA
DoCM (Curated mutations)SRPRA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRPRA (select a term)
intoGenSRPRA
Cancer3DSRPRA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182180   
Orphanet
DisGeNETSRPRA
MedgenSRPRA
Genetic Testing Registry SRPRA
NextProtP08240 [Medical]
TSGene6734
GENETestsSRPRA
Target ValidationSRPRA
Huge Navigator SRPRA [HugePedia]
snp3D : Map Gene to Disease6734
BioCentury BCIQSRPRA
ClinGenSRPRA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6734
Chemical/Pharm GKB GenePA36131
Clinical trialSRPRA
Miscellaneous
canSAR (ICR)SRPRA (select the gene name)
DataMed IndexSRPRA
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRPRA
EVEXSRPRA
GoPubMedSRPRA
iHOPSRPRA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Sep 3 16:08:43 CEST 2019
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