SRRM4 (serine/arginine repetitive matrix 4)

2014-06-01  

Identity

HGNC
SRRM4
LOCATION
12q24.23
LOCUSID
84530
ALIAS
KIAA1853,MU-MB-2.76,nSR100
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84530
MIM: 613103
HGNC: 29389
Ensembl: ENSG00000139767

Variants:

dbSNP: 84530
ClinVar: 84530
TCGA: ENSG00000139767
COSMIC: SRRM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139767ENST00000267260A7MD48
ENSG00000139767ENST00000267260V5T9A0
ENSG00000139767ENST00000641899A0A286YF08

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
255258732014A highly conserved program of neuronal microexons is misregulated in autistic brains.150
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
260714812015SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer.46
271800642017SRRM4 Drives Neuroendocrine Transdifferentiation of Prostate Adenocarcinoma Under Androgen Receptor Pathway Inhibition.43
279847432016Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.25
239280582013The small cell lung cancer-specific isoform of RE1-silencing transcription factor (REST) is regulated by neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100).12
301559922019SRRM4 gene expression correlates with neuroendocrine prostate cancer.7
301003952018A novel mechanism of SRRM4 in promoting neuroendocrine prostate cancer development via a pluripotency gene network.6
297594852018Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer.5

Citation

Dessen P

SRRM4 (serine/arginine repetitive matrix 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53931/srrm4