SRSF5 (serine and arginine rich splicing factor 5)

2018-02-01  

Identity

HGNC
SRSF5
LOCATION
14q24.1
LOCUSID
6430
ALIAS
HRS,SFRS5,SRP40
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6430
MIM: 600914
HGNC: 10787
Ensembl: ENSG00000100650

Variants:

dbSNP: 6430
ClinVar: 6430
TCGA: ENSG00000100650
COSMIC: SRSF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100650ENST00000394366Q13243
ENSG00000100650ENST00000394366A0A024R6D8
ENSG00000100650ENST00000553369B4DUA4
ENSG00000100650ENST00000553521Q13243
ENSG00000100650ENST00000553521A0A024R6D8
ENSG00000100650ENST00000553548G3V5K8
ENSG00000100650ENST00000553635Q13243
ENSG00000100650ENST00000554021B4DUA4
ENSG00000100650ENST00000555349B4DJK0
ENSG00000100650ENST00000555547B4DUA4
ENSG00000100650ENST00000557154Q13243
ENSG00000100650ENST00000557154A0A024R6D8

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
126655902003Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation.49
151637452004A bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates human immunodeficiency virus type 1 rev, env, vpu, and nef gene expression.45
151236772004Differential effects of the SR proteins 9G8, SC35, ASF/SF2, and SRp40 on the utilization of the A1 to A5 splicing sites of HIV-1 RNA.35
204275422010SRp40 and SRp55 promote the translation of unspliced human immunodeficiency virus type 1 RNA.31
169902812006Biochemical and NMR study on the competition between proteins SC35, SRp40, and heterogeneous nuclear ribonucleoprotein A1 at the HIV-1 Tat exon 2 splicing site.24
222056022012Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells.16
275659152016SRSF5: a novel marker for small-cell lung cancer and pleural metastatic cancer.12
198435762010Antagonistic roles of four SR proteins in the biosynthesis of alternatively spliced tissue factor transcripts in monocytic cells.11
288542572017HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection.11
203763282010Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders.10

Citation

Dessen P

SRSF5 (serine and arginine rich splicing factor 5)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57290/srsf5