SRSF7 (serine and arginine rich splicing factor 7)

2013-06-01  

Identity

HGNC
LOCATION
2p22.1
LOCUSID
ALIAS
9G8,AAG3,SFRS7
FUSION GENES

Other Information

Locus ID:

NCBI: 6432
MIM: 600572
HGNC: 10789
Ensembl: ENSG00000115875

Variants:

dbSNP: 6432
ClinVar: 6432
TCGA: ENSG00000115875
COSMIC: SRSF7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115875ENST00000313117Q16629
ENSG00000115875ENST00000409276C9JAB2
ENSG00000115875ENST00000415527F8WEA1
ENSG00000115875ENST00000425778A0A0B4J1Z1
ENSG00000115875ENST00000425941A0A0B4J1Z1
ENSG00000115875ENST00000431066Q16629
ENSG00000115875ENST00000432873H7C1N1
ENSG00000115875ENST00000443213Q16629
ENSG00000115875ENST00000446327Q16629
ENSG00000115875ENST00000452806H7BZZ6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA Splicing - Minor PathwayREACTOMER-HSA-72165
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
152109562004A molecular link between SR protein dephosphorylation and mRNA export.109
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
175133032007The shuttling SR protein 9G8 plays a role in translation of unspliced mRNA containing a constitutive transport element.41
151236772004Differential effects of the SR proteins 9G8, SC35, ASF/SF2, and SRp40 on the utilization of the A1 to A5 splicing sites of HIV-1 RNA.35
159072172005Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production.31
202271042010SR proteins SRp20 and 9G8 contribute to efficient export of herpes simplex virus 1 mRNAs.31
254825082015Genome-wide identification of Fas/CD95 alternative splicing regulators reveals links with iron homeostasis.30
198541362009HIV-1 mRNA 3' end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8.26
171377912007SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations.23
212154882012Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A.14

Citation

Dessen P

SRSF7 (serine and arginine rich splicing factor 7)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53403/srsf7