Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SRSF8 (serine and arginine rich splicing factor 8)

Identity

Alias_namesSFRS2B
splicing factor, arginine/serine-rich 2B
serine/arginine-rich splicing factor 8
Alias_symbol (synonym)SRP46
Other aliasDSM-1
HGNC (Hugo) SRSF8
LocusID (NCBI) 10929
Atlas_Id 74252
Location 11q21  [Link to chromosome band 11q21]
Location_base_pair Starts at 95066877 and ends at 95071224 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SRSF8   16988
Cards
Entrez_Gene (NCBI)SRSF8  10929  serine and arginine rich splicing factor 8
AliasesDSM-1; SFRS2B; SRP46
GeneCards (Weizmann)SRSF8
Ensembl hg19 (Hinxton)ENSG00000263465 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000263465 [Gene_View]  ENSG00000263465 [Sequence]  chr11:95066877-95071224 [Contig_View]  SRSF8 [Vega]
ICGC DataPortalENSG00000263465
TCGA cBioPortalSRSF8
AceView (NCBI)SRSF8
Genatlas (Paris)SRSF8
WikiGenes10929
SOURCE (Princeton)SRSF8
Genetics Home Reference (NIH)SRSF8
Genomic and cartography
GoldenPath hg38 (UCSC)SRSF8  -     chr11:95066877-95071224 +  11q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRSF8  -     11q21   [Description]    (hg19-Feb_2009)
GoldenPathSRSF8 - 11q21 [CytoView hg19]  SRSF8 - 11q21 [CytoView hg38]
ImmunoBaseENSG00000263465
Mapping of homologs : NCBISRSF8 [Mapview hg19]  SRSF8 [Mapview hg38]
OMIM603269   
Gene and transcription
Genbank (Entrez)AF031166 AJ270685 AK023379 AK309776 AK312514
RefSeq transcript (Entrez)NM_032102
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRSF8
Cluster EST : UnigeneHs.703293 [ NCBI ]
CGAP (NCI)Hs.703293
Alternative Splicing GalleryENSG00000263465
Gene ExpressionSRSF8 [ NCBI-GEO ]   SRSF8 [ EBI - ARRAY_EXPRESS ]   SRSF8 [ SEEK ]   SRSF8 [ MEM ]
Gene Expression Viewer (FireBrowse)SRSF8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10929
GTEX Portal (Tissue expression)SRSF8
Human Protein AtlasENSG00000263465-SRSF8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BRL6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BRL6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BRL6
Splice isoforms : SwissVarQ9BRL6
PhosPhoSitePlusQ9BRL6
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)SRSF8
DMDM Disease mutations10929
Blocks (Seattle)SRSF8
PDB (RSDB)2DNM   
PDB Europe2DNM   
PDB (PDBSum)2DNM   
PDB (IMB)2DNM   
Structural Biology KnowledgeBase2DNM   
SCOP (Structural Classification of Proteins)2DNM   
CATH (Classification of proteins structures)2DNM   
SuperfamilyQ9BRL6
Human Protein Atlas [tissue]ENSG00000263465-SRSF8 [tissue]
Peptide AtlasQ9BRL6
HPRD04466
IPIIPI00477842   IPI00856075   IPI00739666   
Protein Interaction databases
DIP (DOE-UCLA)Q9BRL6
IntAct (EBI)Q9BRL6
FunCoupENSG00000263465
BioGRIDSRSF8
STRING (EMBL)SRSF8
ZODIACSRSF8
Ontologies - Pathways
QuickGOQ9BRL6
Ontology : AmiGOregulation of alternative mRNA splicing, via spliceosome  RNA binding  RNA binding  protein binding  nucleus  nucleus  cytoplasm  cytosol  nuclear speck  nuclear speck  mRNA cis splicing, via spliceosome  
Ontology : EGO-EBIregulation of alternative mRNA splicing, via spliceosome  RNA binding  RNA binding  protein binding  nucleus  nucleus  cytoplasm  cytosol  nuclear speck  nuclear speck  mRNA cis splicing, via spliceosome  
NDEx NetworkSRSF8
Atlas of Cancer Signalling NetworkSRSF8
Wikipedia pathwaysSRSF8
Orthology - Evolution
OrthoDB10929
GeneTree (enSembl)ENSG00000263465
Phylogenetic Trees/Animal Genes : TreeFamSRSF8
HOGENOMQ9BRL6
Homologs : HomoloGeneSRSF8
Homology/Alignments : Family Browser (UCSC)SRSF8
Gene fusions - Rearrangements
Fusion : QuiverSRSF8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRSF8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRSF8
dbVarSRSF8
ClinVarSRSF8
1000_GenomesSRSF8 
Exome Variant ServerSRSF8
ExAC (Exome Aggregation Consortium)ENSG00000263465
GNOMAD BrowserENSG00000263465
Varsome BrowserSRSF8
Genetic variants : HAPMAP10929
Genomic Variants (DGV)SRSF8 [DGVbeta]
DECIPHERSRSF8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRSF8 
Mutations
ICGC Data PortalSRSF8 
TCGA Data PortalSRSF8 
Broad Tumor PortalSRSF8
OASIS PortalSRSF8 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSRSF8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRSF8
DgiDB (Drug Gene Interaction Database)SRSF8
DoCM (Curated mutations)SRSF8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRSF8 (select a term)
intoGenSRSF8
Cancer3DSRSF8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603269   
Orphanet
DisGeNETSRSF8
MedgenSRSF8
Genetic Testing Registry SRSF8
NextProtQ9BRL6 [Medical]
TSGene10929
GENETestsSRSF8
Target ValidationSRSF8
Huge Navigator SRSF8 [HugePedia]
snp3D : Map Gene to Disease10929
BioCentury BCIQSRSF8
ClinGenSRSF8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10929
Chemical/Pharm GKB GenePA165543687
Clinical trialSRSF8
Miscellaneous
canSAR (ICR)SRSF8 (select the gene name)
DataMed IndexSRSF8
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRSF8
EVEXSRSF8
GoPubMedSRSF8
iHOPSRSF8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Sep 3 16:08:44 CEST 2019
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