SSB (small RNA binding exonuclease protection factor La)

2007-02-01  

Identity

HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
LARP3,La,La/SSB
FUSION GENES

Other Information

Locus ID:

NCBI: 6741
MIM: 109090
HGNC: 11316
Ensembl: ENSG00000138385

Variants:

dbSNP: 6741
ClinVar: 6741
TCGA: ENSG00000138385
COSMIC: SSB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138385ENST00000260956P05455
ENSG00000138385ENST00000409333P05455
ENSG00000138385ENST00000413002E9PFL9
ENSG00000138385ENST00000417292E9PGX9
ENSG00000138385ENST00000422006E7ERC4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Systemic lupus erythematosusKEGGko05322
Systemic lupus erythematosusKEGGhsa05322
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription TerminationREACTOMER-HSA-73980

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
367688952023NMR Analysis Suggests Synergy between the RRM2 and the Carboxy-Terminal Segment of Human La Protein in the Recognition and Interaction with HCV IRES.0
367857882023Upregulated SSB Is Involved in Hepatocellular Carcinoma Progression and Metastasis through the Epithelial-Mesenchymal Transition, Antiapoptosis, and Altered ROS Level Pathway.0
367688952023NMR Analysis Suggests Synergy between the RRM2 and the Carboxy-Terminal Segment of Human La Protein in the Recognition and Interaction with HCV IRES.0
367857882023Upregulated SSB Is Involved in Hepatocellular Carcinoma Progression and Metastasis through the Epithelial-Mesenchymal Transition, Antiapoptosis, and Altered ROS Level Pathway.0
346361742022The RNA-binding protein La/SSB associates with radiation-induced DNA double-strand breaks in lung cancer cell lines.1
346361742022The RNA-binding protein La/SSB associates with radiation-induced DNA double-strand breaks in lung cancer cell lines.1
332886772021RNA-binding proteins La and HuR cooperatively modulate translation repression of PDCD4 mRNA.7
334848782021Sjögren Syndrome antigen B regulates LIN28-let-7 axis in Caenorhabditis elegans and human.2
332886772021RNA-binding proteins La and HuR cooperatively modulate translation repression of PDCD4 mRNA.7
334848782021Sjögren Syndrome antigen B regulates LIN28-let-7 axis in Caenorhabditis elegans and human.2
331974622020Functional and Structural Aspects of La Protein Overexpression in Lung Cancer.4
331974622020Functional and Structural Aspects of La Protein Overexpression in Lung Cancer.4
290848112018SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability.6
294473942018Human La binds mRNAs through contacts to the poly(A) tail.10
290848112018SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability.6

Citation

Dessen P

SSB (small RNA binding exonuclease protection factor La)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43885/ssb