SSB (small RNA binding exonuclease protection factor La)

2007-02-01  

Identity

HGNC
SSB
LOCATION
2q31.1
LOCUSID
6741
ALIAS
LARP3,La,La/SSB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6741
MIM: 109090
HGNC: 11316
Ensembl: ENSG00000138385

Variants:

dbSNP: 6741
ClinVar: 6741
TCGA: ENSG00000138385
COSMIC: SSB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138385ENST00000260956P05455
ENSG00000138385ENST00000409333P05455
ENSG00000138385ENST00000413002E9PFL9
ENSG00000138385ENST00000417292E9PGX9
ENSG00000138385ENST00000422006E7ERC4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Systemic lupus erythematosusKEGGko05322
Systemic lupus erythematosusKEGGhsa05322
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription TerminationREACTOMER-HSA-73980

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163876552006Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen.68
166825242006Epstein-Barr virus noncoding RNAs are confined to the nucleus, whereas their partner, the human La protein, undergoes nucleocytoplasmic shuttling.53
169062252006Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block.50
146365862003Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs.48
150045492004Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.47
158236072005Role of La autoantigen and polypyrimidine tract-binding protein in HCV replication.40
120497462002Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs.39
185475182008Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein.36
150843962004La protein binds to NS5 and NS3 and to the 5' and 3' ends of Dengue 4 virus RNA.33
125408502003Hepatitis C virus internal ribosome entry site-mediated translation is stimulated by specific interaction of independent regions of human La autoantigen.31

Citation

Dessen P

SSB (small RNA binding exonuclease protection factor La)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43885/ssb