SSTR3 (somatostatin receptor 3)

2003-02-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
SS-3-R,SS3-R,SS3R,SSR-28

Other Information

Locus ID:

NCBI: 6753
MIM: 182453
HGNC: 11332
Ensembl: ENSG00000278195

Variants:

dbSNP: 6753
ClinVar: 6753
TCGA: ENSG00000278195
COSMIC: SSTR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000278195ENST00000610913P32745
ENSG00000278195ENST00000617123P32745

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
BBSome-mediated cargo-targeting to ciliumREACTOMER-HSA-5620922
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
333720372021HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.13
333720372021HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.13
264744342016Prognostic Value of Somatostatin Receptor Subtypes in Pancreatic Neuroendocrine Tumors.12
271013762016Identification of Phosphorylation Sites Regulating sst3 Somatostatin Receptor Trafficking.9
264744342016Prognostic Value of Somatostatin Receptor Subtypes in Pancreatic Neuroendocrine Tumors.12
271013762016Identification of Phosphorylation Sites Regulating sst3 Somatostatin Receptor Trafficking.9
255363182015Dopamine 2 and somatostatin 1-5 receptors coexpression in clinically non-functioning pituitary adenomas.11
255540892015Increased SSTR2A and SSTR3 expression in succinate dehydrogenase-deficient pheochromocytomas and paragangliomas.31
258081612015Somatostatin and dopamine receptor expression in neuroendocrine neoplasms: correlation of immunohistochemical findings with somatostatin receptor scintigraphy visual scores.19
259624062015An immunohistochemical investigation of the expression of somatostatin receptor subtypes - should therapeutic trials be performed to determine the efficacy of somatostatin analogs in treating advanced thyroid malignances?4
261121832015Human somatostatin receptor-3 distinctively induces apoptosis in MCF-7 and cell cycle arrest in MDA-MB-231 breast cancer cells.8
255363182015Dopamine 2 and somatostatin 1-5 receptors coexpression in clinically non-functioning pituitary adenomas.11
255540892015Increased SSTR2A and SSTR3 expression in succinate dehydrogenase-deficient pheochromocytomas and paragangliomas.31
258081612015Somatostatin and dopamine receptor expression in neuroendocrine neoplasms: correlation of immunohistochemical findings with somatostatin receptor scintigraphy visual scores.19
259624062015An immunohistochemical investigation of the expression of somatostatin receptor subtypes - should therapeutic trials be performed to determine the efficacy of somatostatin analogs in treating advanced thyroid malignances?4

Citation

Dessen P

SSTR3 (somatostatin receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42403/sstr3