SSU72 (SSU72 homolog, RNA polymerase II CTD phosphatase)

2014-08-01  

Identity

HGNC
SSU72
LOCATION
1p36.33
LOCUSID
29101
ALIAS
HSPC182,PNAS-120
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29101
MIM: 617680
HGNC: 25016
Ensembl: ENSG00000160075

Variants:

dbSNP: 29101
ClinVar: 29101
TCGA: ENSG00000160075
COSMIC: SSU72

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160075ENST00000291386Q9NP77
ENSG00000160075ENST00000359060Q9NP77

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208618392010Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.74
230708122012An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72.20
156595782005Conserved and specific functions of mammalian ssu72.12
208183332010The hsSsu72 phosphatase is a cohesin-binding protein that regulates the resolution of sister chromatid arm cohesion.5
241498582013Functional interplay between Aurora B kinase and Ssu72 phosphatase regulates sister chromatid cohesion.4
185970382009High resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral density.3
291582572018Structural dissection of an interaction between transcription initiation and termination factors implicated in promoter-terminator cross-talk.3
309013322019Functional interaction of human Ssu72 with RNA polymerase II complexes.0

Citation

Dessen P

SSU72 (SSU72 homolog, RNA polymerase II CTD phosphatase)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54671/ssu72