Identity
HGNC
LOCATION
11q24.3
LOCUSID
ALIAS
ARCI11,CAP3,HAI,MT-SP1,MTSP1,PRSS14,SNC19,TADG15,TMPRSS14
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6768
MIM: 606797
HGNC: 11344
Ensembl: ENSG00000149418
Variants:
dbSNP: 6768
ClinVar: 6768
TCGA: ENSG00000149418
COSMIC: ST14
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000149418 | ENST00000278742 | Q9Y5Y6 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38547126 | 2024 | Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion. | 0 |
| 38547126 | 2024 | Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion. | 0 |
| 35020274 | 2022 | Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor-1. | 2 |
| 35950457 | 2022 | Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer Cells by Producing CCL2. | 0 |
| 35964051 | 2022 | Novel mutations of the ABCA12, KRT1 and ST14 genes in three unrelated newborns showing congenital ichthyosis. | 6 |
| 35020274 | 2022 | Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor-1. | 2 |
| 35950457 | 2022 | Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer Cells by Producing CCL2. | 0 |
| 35964051 | 2022 | Novel mutations of the ABCA12, KRT1 and ST14 genes in three unrelated newborns showing congenital ichthyosis. | 6 |
| 34418985 | 2021 | Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer. | 2 |
| 34418985 | 2021 | Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer. | 2 |
| 32241917 | 2020 | A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CβII. | 5 |
| 32326212 | 2020 | Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins. | 13 |
| 32493324 | 2020 | Intramembrane proteolysis of an extracellular serine protease, epithin/PRSS14, enables its intracellular nuclear function. | 2 |
| 32761920 | 2020 | Proteolytic cleavage of Trop2 at Arg87 is mediated by matriptase and regulated by Val194. | 7 |
| 33094801 | 2020 | Insights into the regulation of the matriptase-prostasin proteolytic system. | 2 |
Citation
Dessen P
ST14 (ST14 transmembrane serine protease matriptase)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42418/st14
