ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1)

2010-02-01  

Identity

HGNC
ST3GAL1
LOCATION
8q24.22
LOCUSID
6482
ALIAS
Gal-NAc6S,SIAT4A,SIATFL,ST3GalA,ST3GalA.1,ST3GalIA,ST3GalIA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6482
MIM: 607187
HGNC: 10862
Ensembl: ENSG00000008513

Variants:

dbSNP: 6482
ClinVar: 6482
TCGA: ENSG00000008513
COSMIC: ST3GAL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008513ENST00000399640Q11201
ENSG00000008513ENST00000399640A0A024R9L6
ENSG00000008513ENST00000517668E5RGL4
ENSG00000008513ENST00000519924E5RGI3
ENSG00000008513ENST00000521180Q11201
ENSG00000008513ENST00000521180A0A024R9L6
ENSG00000008513ENST00000522652Q11201
ENSG00000008513ENST00000522652A0A024R9L6
ENSG00000008513ENST00000523634E5RH34
ENSG00000008513ENST00000523854E5RHV6
ENSG00000008513ENST00000523855E5RG72
ENSG00000008513ENST00000648219Q11201
ENSG00000008513ENST00000648219A0A024R9L6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Mucin type O-glycan biosynthesisKEGGko00512
Glycosaminoglycan biosynthesis - keratan sulfateKEGGko00533
Glycosphingolipid biosynthesis - ganglio seriesKEGGko00604
Mucin type O-glycan biosynthesisKEGGhsa00512
Glycosaminoglycan biosynthesis - keratan sulfateKEGGhsa00533
Glycosphingolipid biosynthesis - globo and isoglobo seriesKEGGhsa00603
Glycosphingolipid biosynthesis - ganglio seriesKEGGhsa00604
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Sialic acid metabolismREACTOMER-HSA-4085001
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Termination of O-glycan biosynthesisREACTOMER-HSA-977068
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Keratan sulfate/keratin metabolismREACTOMER-HSA-1638074
Keratan sulfate biosynthesisREACTOMER-HSA-2022854

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
198116342009ST3Gal.I sialyltransferase relevance in bladder cancer tissues and cell lines.39
205345932010Over-expression of ST3Gal-I promotes mammary tumorigenesis.38
147221112004Structure-function analysis of the human sialyltransferase ST3Gal I: role of n-glycosylation and a novel conserved sialylmotif.29
181804292008Family-based association study of lithium-related and other candidate genes in bipolar disorder.26
181804292008Family-based association study of lithium-related and other candidate genes in bipolar disorder.26
250860692014Restoration of compact Golgi morphology in advanced prostate cancer enhances susceptibility to galectin-1-induced apoptosis by modifying mucin O-glycan synthesis.23
171017702007Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosis.22
179476422007Sialyl-Lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: a mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I.18

Citation

Dessen P

ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51334/st3gal1