ST3GAL2 (ST3 beta-galactoside alpha-2,3-sialyltransferase 2)

2009-01-01 Affiliation

Identity

HGNC

ST3GAL2

LOCATION

16q22.1

LOCUSID

6483

ALIAS

Gal-NAc6S,SIAT4B,ST3GALII,ST3GalA.2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6483
MIM: 607188
HGNC: 10863
Ensembl: ENSG00000157350

Variants:

dbSNP: 6483
ClinVar: 6483
TCGA: ENSG00000157350
COSMIC: ST3GAL2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000157350	ENST00000342907	Q16842
ENSG00000157350	ENST00000342907	A0A024QZA4
ENSG00000157350	ENST00000393640	Q16842
ENSG00000157350	ENST00000393640	A0A024QZA4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Mucin type O-glycan biosynthesis	KEGG	ko00512
Glycosaminoglycan biosynthesis - keratan sulfate	KEGG	ko00533
Glycosphingolipid biosynthesis - ganglio series	KEGG	ko00604
Mucin type O-glycan biosynthesis	KEGG	hsa00512
Glycosaminoglycan biosynthesis - keratan sulfate	KEGG	hsa00533
Glycosphingolipid biosynthesis - globo and isoglobo series	KEGG	hsa00603
Glycosphingolipid biosynthesis - ganglio series	KEGG	hsa00604
Metabolic pathways	KEGG	hsa01100
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	REACTOME	R-HSA-446193
Synthesis of substrates in N-glycan biosythesis	REACTOME	R-HSA-446219
Sialic acid metabolism	REACTOME	R-HSA-4085001
O-linked glycosylation	REACTOME	R-HSA-5173105
O-linked glycosylation of mucins	REACTOME	R-HSA-913709
Termination of O-glycan biosynthesis	REACTOME	R-HSA-977068
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glycosaminoglycan metabolism	REACTOME	R-HSA-1630316
Keratan sulfate/keratin metabolism	REACTOME	R-HSA-1638074
Keratan sulfate biosynthesis	REACTOME	R-HSA-2022854

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12716912	2003	Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase.	19
25916169	2015	Critical role of evolutionarily conserved glycosylation at Asn211 in the intracellular trafficking and activity of sialyltransferase ST3Gal-II.	3
12504121	2003	Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene.	2
28698248	2017	Ganglioside glycosyltransferases are S-acylated at conserved cysteine residues involved in homodimerisation.	1

Citation

Dessen P

ST3GAL2 (ST3 beta-galactoside alpha-2,3-sialyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50652/st3gal2