ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6)

2008-09-01  

Identity

HGNC
ST3GAL6
LOCATION
3q12.1
LOCUSID
10402
ALIAS
SIAT10,ST3GALVI
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10402
MIM: 607156
HGNC: 18080
Ensembl: ENSG00000064225

Variants:

dbSNP: 10402
ClinVar: 10402
TCGA: ENSG00000064225
COSMIC: ST3GAL6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064225ENST00000265261Q9Y274
ENSG00000064225ENST00000394162Q9Y274
ENSG00000064225ENST00000460774C9JWI9
ENSG00000064225ENST00000468553C9JMW7
ENSG00000064225ENST00000469105F2Z2F4
ENSG00000064225ENST00000476833F2Z2F4
ENSG00000064225ENST00000477574C9JXM2
ENSG00000064225ENST00000483910Q9Y274
ENSG00000064225ENST00000485145C9JWJ3
ENSG00000064225ENST00000485391C9IZL6
ENSG00000064225ENST00000486249F2Z2F4
ENSG00000064225ENST00000486334C9J0E2
ENSG00000064225ENST00000492254C9J480
ENSG00000064225ENST00000495376F2Z2F4
ENSG00000064225ENST00000497008C9J9Y4
ENSG00000064225ENST00000497621F8WC98
ENSG00000064225ENST00000613264A0A087WXB8

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Sialic acid metabolismREACTOMER-HSA-4085001
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Processing in GolgiREACTOMER-HSA-1912420
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Keratan sulfate/keratin metabolismREACTOMER-HSA-1638074
Keratan sulfate biosynthesisREACTOMER-HSA-2022854

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
250611762014The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma.39
205322022010Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.34
197816612010Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells.33
184859152008DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.31
211477602011Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.6

Citation

Dessen P

ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50332/st3gal6