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ST5 (suppression of tumorigenicity 5)

Identity

Alias_symbol (synonym)HTS1
DENND2B
p126
Other alias
HGNC (Hugo) ST5
LocusID (NCBI) 6764
Atlas_Id 42423
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 8693352 and ends at 8810677 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DUSP1 (5q35.1) / ST5 (11p15.4)EIF3I (1p35.1) / ST5 (11p15.4)NMT1 (17q21.31) / ST5 (11p15.4)
ST5 (11p15.4) / DENND5A (11p15.4)ST5 (11p15.4) / GPT2 (16q11.2)ST5 (11p15.4) / LEXM (1p32.3)
ST5 (11p15.4) / PRODH (22q11.21)ST5 11p15.4 / DENND5A 11p15.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  ST5/DENND5A (11p15)


External links

Nomenclature
HGNC (Hugo)ST5   11350
Cards
Entrez_Gene (NCBI)ST5  6764  suppression of tumorigenicity 5
AliasesDENND2B; HTS1; p126
GeneCards (Weizmann)ST5
Ensembl hg19 (Hinxton)ENSG00000166444 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166444 [Gene_View]  ENSG00000166444 [Sequence]  chr11:8693352-8810677 [Contig_View]  ST5 [Vega]
ICGC DataPortalENSG00000166444
TCGA cBioPortalST5
AceView (NCBI)ST5
Genatlas (Paris)ST5
WikiGenes6764
SOURCE (Princeton)ST5
Genetics Home Reference (NIH)ST5
Genomic and cartography
GoldenPath hg38 (UCSC)ST5  -     chr11:8693352-8810677 -  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ST5  -     11p15.4   [Description]    (hg19-Feb_2009)
GoldenPathST5 - 11p15.4 [CytoView hg19]  ST5 - 11p15.4 [CytoView hg38]
ImmunoBaseENSG00000166444
Mapping of homologs : NCBIST5 [Mapview hg19]  ST5 [Mapview hg38]
OMIM140750   
Gene and transcription
Genbank (Entrez)AK126554 AK127763 AK293245 AK302824 AK307617
RefSeq transcript (Entrez)NM_005418 NM_139157 NM_213618
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ST5
Cluster EST : UnigeneHs.117715 [ NCBI ]
CGAP (NCI)Hs.117715
Alternative Splicing GalleryENSG00000166444
Gene ExpressionST5 [ NCBI-GEO ]   ST5 [ EBI - ARRAY_EXPRESS ]   ST5 [ SEEK ]   ST5 [ MEM ]
Gene Expression Viewer (FireBrowse)ST5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6764
GTEX Portal (Tissue expression)ST5
Human Protein AtlasENSG00000166444-ST5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78524   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78524  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78524
Splice isoforms : SwissVarP78524
PhosPhoSitePlusP78524
Domaine pattern : Prosite (Expaxy)DENN (PS50211)   
Domains : Interpro (EBI)cDENN_dom    dDENN_dom    Tripartite_DENN    uDENN_dom   
Domain families : Pfam (Sanger)dDENN (PF03455)    DENN (PF02141)    uDENN (PF03456)   
Domain families : Pfam (NCBI)pfam03455    pfam02141    pfam03456   
Domain families : Smart (EMBL)dDENN (SM00801)  DENN (SM00799)  uDENN (SM00800)  
Conserved Domain (NCBI)ST5
DMDM Disease mutations6764
Blocks (Seattle)ST5
SuperfamilyP78524
Human Protein Atlas [tissue]ENSG00000166444-ST5 [tissue]
Peptide AtlasP78524
HPRD00780
IPIIPI00298518   IPI00162743   IPI00783821   IPI00748001   IPI00984342   IPI00978391   IPI00978362   IPI00980824   IPI00979094   IPI00977136   IPI00983183   IPI00909423   IPI00983156   IPI00976106   IPI00976633   IPI00984988   IPI00979891   IPI00976119   IPI00983135   IPI00975964   IPI00980855   IPI00976041   IPI01021595   IPI00981125   IPI00985016   IPI00980264   IPI00982609   IPI00981650   IPI00982967   IPI00983820   IPI00984329   IPI00976046   IPI00984965   IPI00982654   IPI00977890   IPI00980296   IPI00982012   IPI00979615   IPI00981471   IPI00977855   IPI00977171   
Protein Interaction databases
DIP (DOE-UCLA)P78524
IntAct (EBI)P78524
FunCoupENSG00000166444
BioGRIDST5
STRING (EMBL)ST5
ZODIACST5
Ontologies - Pathways
QuickGOP78524
Ontology : AmiGOplasma membrane  cell cortex  Rab guanyl-nucleotide exchange factor activity  recycling endosome  
Ontology : EGO-EBIplasma membrane  cell cortex  Rab guanyl-nucleotide exchange factor activity  recycling endosome  
NDEx NetworkST5
Atlas of Cancer Signalling NetworkST5
Wikipedia pathwaysST5
Orthology - Evolution
OrthoDB6764
GeneTree (enSembl)ENSG00000166444
Phylogenetic Trees/Animal Genes : TreeFamST5
HOGENOMP78524
Homologs : HomoloGeneST5
Homology/Alignments : Family Browser (UCSC)ST5
Gene fusions - Rearrangements
Fusion : MitelmanST5/DENND5A [11p15.4/11p15.4]  
Fusion PortalST5 11p15.4 DENND5A 11p15.4 BRCA
Fusion Cancer (Beijing)ST5 [11p15.4]  -  PRODH [22q11.21]  [FUSC003118]
Fusion : QuiverST5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerST5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ST5
dbVarST5
ClinVarST5
1000_GenomesST5 
Exome Variant ServerST5
ExAC (Exome Aggregation Consortium)ENSG00000166444
GNOMAD BrowserENSG00000166444
Varsome BrowserST5
Genetic variants : HAPMAP6764
Genomic Variants (DGV)ST5 [DGVbeta]
DECIPHERST5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisST5 
Mutations
ICGC Data PortalST5 
TCGA Data PortalST5 
Broad Tumor PortalST5
OASIS PortalST5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICST5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DST5
Mutations and Diseases : HGMDST5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ST5
DgiDB (Drug Gene Interaction Database)ST5
DoCM (Curated mutations)ST5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ST5 (select a term)
intoGenST5
Cancer3DST5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM140750   
Orphanet
DisGeNETST5
MedgenST5
Genetic Testing Registry ST5
NextProtP78524 [Medical]
TSGene6764
GENETestsST5
Target ValidationST5
Huge Navigator ST5 [HugePedia]
snp3D : Map Gene to Disease6764
BioCentury BCIQST5
ClinGenST5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6764
Chemical/Pharm GKB GenePA36172
Clinical trialST5
Miscellaneous
canSAR (ICR)ST5 (select the gene name)
DataMed IndexST5
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineST5
EVEXST5
GoPubMedST5
iHOPST5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:09:55 CET 2019

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