STAG3 (stromal antigen 3)

2007-04-01  

Identity

HGNC
STAG3
LOCATION
7q22.1
LOCUSID
10734
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10734
MIM: 608489
HGNC: 11356
Ensembl: ENSG00000066923

Variants:

dbSNP: 10734
ClinVar: 10734
TCGA: ENSG00000066923
COSMIC: STAG3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000066923ENST00000317296Q9UJ98
ENSG00000066923ENST00000394018Q9UJ98
ENSG00000066923ENST00000412190H7C0H6
ENSG00000066923ENST00000416412C9JTG4
ENSG00000066923ENST00000422690C9JYW5
ENSG00000066923ENST00000426455Q9UJ98
ENSG00000066923ENST00000439782C9J3T3
ENSG00000066923ENST00000451963H0Y4S6
ENSG00000066923ENST00000615138D6W5U7
ENSG00000066923ENST00000620100Q9UJ98

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
182995612008Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.167
245978672014Mutant cohesin in premature ovarian failure.64
206353892011Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.25
206353892011Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.25
275007262016Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.17
192700262009Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival.11
260598402016STAG3 truncating variant as the cause of primary ovarian insufficiency.9
283933512018Whole-exome sequencing identifies a homozygous donor splice-site mutation in STAG3 that causes primary ovarian insufficiency.6
297249142018Studying meiotic cohesin in somatic cells reveals that Rec8-containing cohesin requires Stag3 to function and is regulated by Wapl and sororin.6
288027122017A STAG3 missense mutation in two sisters with primary ovarian insufficiency.4

Citation

Dessen P

STAG3 (stromal antigen 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46840/stag3