STAM2 (signal transducing adaptor molecule 2)

2014-07-01  

Identity

HGNC
LOCATION
2q23.3
LOCUSID
ALIAS
Hbp,STAM2A,STAM2B
FUSION GENES

Other Information

Locus ID:

NCBI: 10254
MIM: 606244
HGNC: 11358
Ensembl: ENSG00000115145

Variants:

dbSNP: 10254
ClinVar: 10254
TCGA: ENSG00000115145
COSMIC: STAM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115145ENST00000263904O75886

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Jak-STAT signaling pathwayKEGGhsa04630
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
ESCRT-0 complexKEGGhsa_M00408
ESCRT-0 complexKEGGM00408
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR downregulationREACTOMER-HSA-182971
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)REACTOMER-HSA-917729
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Signaling by METREACTOMER-HSA-6806834
Negative regulation of MET activityREACTOMER-HSA-6807004
Listeria monocytogenes entry into host cellsREACTOMER-HSA-8876384
InlB-mediated entry of Listeria monocytogenes into host cellREACTOMER-HSA-8875360

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205047642010PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2.19
174036762007Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation.17
151138372004Association with Hrs is required for the early endosomal localization, stability, and function of STAM.13
268666052016Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0.8
224934382012Evidence for cooperative and domain-specific binding of the signal transducing adaptor molecule 2 (STAM2) to Lys63-linked diubiquitin.6
190543912009STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking.5
228417192012Competitive binding of UBPY and ubiquitin to the STAM2 SH3 domain revealed by NMR.5
211216352011NMR reveals a different mode of binding of the Stam2 VHS domain to ubiquitin and diubiquitin.4
266019482016The Vps27/Hrs/STAM (VHS) Domain of the Signal-transducing Adaptor Molecule (STAM) Directs Associated Molecule with the SH3 Domain of STAM (AMSH) Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage.3
277251842016NMR Reveals the Interplay among the AMSH SH3 Binding Motif, STAM2, and Lys63-Linked Diubiquitin.2

Citation

Dessen P

STAM2 (signal transducing adaptor molecule 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-07-01

Online version: http://atlasgeneticsoncology.org/gene/54047/stam2