STAMBPL1 (STAM binding protein like 1)

2012-05-01  

Identity

HGNC
LOCATION
10q23.31
LOCUSID
ALIAS
ALMalpha,AMSH-FP,AMSH-LP,bA399O19.2
FUSION GENES

Other Information

Locus ID:

NCBI: 57559
MIM: 612352
HGNC: 24105
Ensembl: ENSG00000138134

Variants:

dbSNP: 57559
ClinVar: 57559
TCGA: ENSG00000138134
COSMIC: STAMBPL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138134ENST00000371924Q96FJ0
ENSG00000138134ENST00000371926Q96FJ0
ENSG00000138134ENST00000371927Q96FJ0

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Metalloprotease DUBsREACTOMER-HSA-5689901

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
222582472012An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation.23
174262872007Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism.16
167161902006Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes.12
128100662003Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif.10
262562342015Quantum Mechanics and Molecular Mechanics Study of the Catalytic Mechanism of Human AMSH-LP Domain Deubiquitinating Enzymes.1
310047022019Targeting the deubiquitinase STAMBPL1 triggers apoptosis in prostate cancer cells by promoting XIAP degradation.1

Citation

Dessen P

STAMBPL1 (STAM binding protein like 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/52702/stambpl1