| Nomenclature |
HGNC (Hugo) | STAT1 11362 |
LRG (Locus Reference Genomic) | LRG_111 |
| Cards |
Entrez_Gene (NCBI) | STAT1 6772 signal transducer and activator of transcription 1 |
Aliases | CANDF7; IMD31A; IMD31B; IMD31C; |
| ISGF-3; STAT91 |
GeneCards (Weizmann) | STAT1 |
Ensembl hg19 (Hinxton) | ENSG00000115415 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000115415 [Gene_View]  ENSG00000115415 [Sequence] chr2:190975537-191014250 [Contig_View] STAT1 [Vega] |
ICGC DataPortal | ENSG00000115415 |
TCGA cBioPortal | STAT1 |
AceView (NCBI) | STAT1 |
Genatlas (Paris) | STAT1 |
WikiGenes | 6772 |
SOURCE (Princeton) | STAT1 |
Genetics Home Reference (NIH) | STAT1 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | STAT1 - chr2:190975537-191014250 - 2q32.2 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | STAT1 - 2q32.2 [Description] (hg19-Feb_2009) |
GoldenPath | STAT1 - 2q32.2 [CytoView hg19] STAT1 - 2q32.2 [CytoView hg38] |
ImmunoBase | ENSG00000115415 |
Mapping of homologs : NCBI | STAT1 [Mapview hg19] STAT1 [Mapview hg38] |
OMIM | 600555 613796 614162 614892 |
| Gene and transcription |
Genbank (Entrez) | AI992149 AK096686 AK225853 AK292604 AK315002 |
RefSeq transcript (Entrez) | NM_007315 NM_139266 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | STAT1 |
Cluster EST : Unigene | Hs.743244 [ NCBI ] |
CGAP (NCI) | Hs.743244 |
Alternative Splicing Gallery | ENSG00000115415 |
Gene Expression | STAT1 [ NCBI-GEO ] STAT1 [ EBI - ARRAY_EXPRESS ]
STAT1 [ SEEK ] STAT1 [ MEM ] |
Gene Expression Viewer (FireBrowse) | STAT1 [ Firebrowse - Broad ] |
SOURCE (Princeton) | Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60] |
Genevestigator | Expression in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 6772 |
GTEX Portal (Tissue expression) | STAT1 |
Human Protein Atlas | ENSG00000115415-STAT1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | P42224 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | P42224 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | P42224 |
Splice isoforms : SwissVar | P42224 |
PhosPhoSitePlus | P42224 |
Domaine pattern : Prosite (Expaxy) | SH2 (PS50001) |
Domains : Interpro (EBI) | p53-like_TF_DNA-bd SH2 SH2_dom_sf STAT STAT1_C_sf STAT1_SH2 STAT1_TAZ2-bd_C STAT_N_sf STAT_TF_alpha STAT_TF_coiled-coil STAT_TF_DNA-bd STAT_TF_DNA-bd_N STAT_TF_prot_interaction |
Domain families : Pfam (Sanger) | SH2 (PF00017) STAT1_TAZ2bind (PF12162) STAT_alpha (PF01017) STAT_bind (PF02864) STAT_int (PF02865) |
Domain families : Pfam (NCBI) | pfam00017 pfam12162 pfam01017 pfam02864 pfam02865 |
Domain families : Smart (EMBL) | STAT_int (SM00964) |
Conserved Domain (NCBI) | STAT1 |
DMDM Disease mutations | 6772 |
Blocks (Seattle) | STAT1 |
PDB (RSDB) | 1BF5 1YVL 2KA6 3WWT |
PDB Europe | 1BF5 1YVL 2KA6 3WWT |
PDB (PDBSum) | 1BF5 1YVL 2KA6 3WWT |
PDB (IMB) | 1BF5 1YVL 2KA6 3WWT |
Structural Biology KnowledgeBase | 1BF5 1YVL 2KA6 3WWT |
SCOP (Structural Classification of Proteins) | 1BF5 1YVL 2KA6 3WWT |
CATH (Classification of proteins structures) | 1BF5 1YVL 2KA6 3WWT |
Superfamily | P42224 |
Human Protein Atlas [tissue] | ENSG00000115415-STAT1 [tissue] |
Peptide Atlas | P42224 |
HPRD | 02777 |
IPI | IPI00030781 IPI00218188 IPI01015490 IPI00795482 IPI00797149 IPI00915952 IPI00915841 IPI00916196 IPI00916067 IPI00916320 |
| Protein Interaction databases |
DIP (DOE-UCLA) | P42224 |
IntAct (EBI) | P42224 |
FunCoup | ENSG00000115415 |
BioGRID | STAT1 |
STRING (EMBL) | STAT1 |
ZODIAC | STAT1 |
| Ontologies - Pathways |
QuickGO | P42224 |
Ontology : AmiGO | negative regulation of transcription by RNA polymerase II nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific negative regulation of endothelial cell proliferation positive regulation of mesenchymal cell proliferation positive regulation of defense response to virus by host positive regulation of defense response to virus by host negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis double-stranded DNA binding DNA-binding transcription factor activity tumor necrosis factor receptor binding protein binding nucleus nucleus nucleus nucleoplasm nucleoplasm nucleolus cytoplasm cytosol cytosol cytosol defense response positive regulation of transcription of Notch receptor target JAK-STAT cascade JAK-STAT cascade response to nutrient blood circulation response to mechanical stimulus macrophage derived foam cell differentiation viral process negative regulation of angiogenesis cytokine-mediated signaling pathway cytokine-mediated signaling pathway enzyme binding axon dendrite CCR5 chemokine receptor binding positive regulation of interferon-alpha production cellular response to insulin stimulus protein-containing complex tumor necrosis factor-mediated signaling pathway response to cytokine histone acetyltransferase binding nuclear hormone receptor binding response to interferon-beta cellular response to interferon-beta interleukin-9-mediated signaling pathway interleukin-21-mediated signaling pathway regulation of cell proliferation histone binding response to hydrogen peroxide identical protein binding protein homodimerization activity regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling response to peptide hormone response to peptide hormone endothelial cell migration ubiquitin-like protein ligase binding cadherin binding positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation by virus of viral protein levels in host cell perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation response to cAMP defense response to virus protein phosphatase 2A binding positive regulation of nitric-oxide synthase biosynthetic process interferon-gamma-mediated signaling pathway interferon-gamma-mediated signaling pathway interferon-gamma-mediated signaling pathway interferon-gamma-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway type I interferon signaling pathway type I interferon signaling pathway type I interferon signaling pathway type I interferon signaling pathway renal tubule development interleukin-6-mediated signaling pathway interleukin-27-mediated signaling pathway repressing transcription factor binding interleukin-35-mediated signaling pathway cellular response to interferon-gamma cellular response to organic cyclic compound metanephric mesenchymal cell proliferation involved in metanephros development metanephric mesenchymal cell differentiation negative regulation of metanephric nephron tubule epithelial cell differentiation promoter-specific chromatin binding |
Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific negative regulation of endothelial cell proliferation positive regulation of mesenchymal cell proliferation positive regulation of defense response to virus by host positive regulation of defense response to virus by host negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis double-stranded DNA binding DNA-binding transcription factor activity tumor necrosis factor receptor binding protein binding nucleus nucleus nucleus nucleoplasm nucleoplasm nucleolus cytoplasm cytosol cytosol cytosol defense response positive regulation of transcription of Notch receptor target JAK-STAT cascade JAK-STAT cascade response to nutrient blood circulation response to mechanical stimulus macrophage derived foam cell differentiation viral process negative regulation of angiogenesis cytokine-mediated signaling pathway cytokine-mediated signaling pathway enzyme binding axon dendrite CCR5 chemokine receptor binding positive regulation of interferon-alpha production cellular response to insulin stimulus protein-containing complex tumor necrosis factor-mediated signaling pathway response to cytokine histone acetyltransferase binding nuclear hormone receptor binding response to interferon-beta cellular response to interferon-beta interleukin-9-mediated signaling pathway interleukin-21-mediated signaling pathway regulation of cell proliferation histone binding response to hydrogen peroxide identical protein binding protein homodimerization activity regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling response to peptide hormone response to peptide hormone endothelial cell migration ubiquitin-like protein ligase binding cadherin binding positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation by virus of viral protein levels in host cell perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation response to cAMP defense response to virus protein phosphatase 2A binding positive regulation of nitric-oxide synthase biosynthetic process interferon-gamma-mediated signaling pathway interferon-gamma-mediated signaling pathway interferon-gamma-mediated signaling pathway interferon-gamma-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway type I interferon signaling pathway type I interferon signaling pathway type I interferon signaling pathway type I interferon signaling pathway renal tubule development interleukin-6-mediated signaling pathway interleukin-27-mediated signaling pathway repressing transcription factor binding interleukin-35-mediated signaling pathway cellular response to interferon-gamma cellular response to organic cyclic compound metanephric mesenchymal cell proliferation involved in metanephros development metanephric mesenchymal cell differentiation negative regulation of metanephric nephron tubule epithelial cell differentiation promoter-specific chromatin binding |
Pathways : KEGG | Chemokine signaling pathway Osteoclast differentiation Toll-like receptor signaling pathway Jak-STAT signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Leishmaniasis Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Influenza A Herpes simplex infection Pathways in cancer Pancreatic cancer Inflammatory bowel disease (IBD) |
NDEx Network | STAT1 |
Atlas of Cancer Signalling Network | STAT1 |
Wikipedia pathways | STAT1 |
| Orthology - Evolution |
OrthoDB | 6772 |
GeneTree (enSembl) | ENSG00000115415 |
Phylogenetic Trees/Animal Genes : TreeFam | STAT1 |
HOGENOM | P42224 |
Homologs : HomoloGene | STAT1 |
Homology/Alignments : Family Browser (UCSC) | STAT1 |
| Gene fusions - Rearrangements |
Fusion : Quiver | STAT1 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | STAT1 [hg38] |
dbSNP Single Nucleotide Polymorphism (NCBI) | STAT1 |
dbVar | STAT1 |
ClinVar | STAT1 |
1000_Genomes | STAT1 |
Exome Variant Server | STAT1 |
ExAC (Exome Aggregation Consortium) | ENSG00000115415 |
GNOMAD Browser | ENSG00000115415 |
Varsome Browser | STAT1 |
Genetic variants : HAPMAP | 6772 |
Genomic Variants (DGV) | STAT1 [DGVbeta] |
DECIPHER | STAT1 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | STAT1 |
| Mutations |
ICGC Data Portal | STAT1 |
TCGA Data Portal | STAT1 |
Broad Tumor Portal | STAT1 |
OASIS Portal | STAT1 [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | STAT1 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | STAT1 |
Mutations and Diseases : HGMD | STAT1 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
LOVD (Leiden Open Variation Database) | Mendelian genes |
LOVD (Leiden Open Variation Database) | **PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database |
BioMuta | search STAT1 |
DgiDB (Drug Gene Interaction Database) | STAT1 |
DoCM (Curated mutations) | STAT1 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | STAT1 (select a term) |
intoGen | STAT1 |
Cancer3D | STAT1(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 600555 613796 614162 614892 |
Orphanet | 21679 22628 22602 |
DisGeNET | STAT1 |
Medgen | STAT1 |
Genetic Testing Registry | STAT1
|
NextProt | P42224 [Medical] |
TSGene | 6772 |
GENETests | STAT1 |
Target Validation | STAT1 |
Huge Navigator |
STAT1 [HugePedia] |
snp3D : Map Gene to Disease | 6772 |
BioCentury BCIQ | STAT1 |
ClinGen | STAT1 (curated) |
| Clinical trials, drugs, therapy |
---|
Chemical/Protein Interactions : CTD | 6772 |
Chemical/Pharm GKB Gene | PA36183 |
Clinical trial | STAT1 |
| Miscellaneous |
---|
canSAR (ICR) | STAT1 (select the gene name) |
DataMed Index | STAT1 |
| Probes |
---|
| Litterature |
---|
PubMed | 499 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
CoreMine | STAT1 |
EVEX | STAT1 |
GoPubMed | STAT1 |
iHOP | STAT1 |