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STAT4 (signal transducer and activator of transcription 4)

Identity

Other namesSLEB11
HGNC (Hugo) STAT4
Location 2q32.3
Location_base_pair Starts at 191602551 and ends at 191724170 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)STAT4   11365
Entrez_Gene (NCBI)STAT4  6775  signal transducer and activator of transcription 4
Cards
GeneCards (Weizmann)STAT4
Ensembl (Hinxton)ENSG00000138378 [Gene_View]  STAT4 [Vega]
AceView (NCBI)STAT4
Genatlas (Paris)STAT4
euGene (Indiana)6775
SOURCE (Stanford)NM_003151
Gene Expression (Array Express) ENSG00000138378
Genomic and cartography
GoldenPath (UCSC)STAT4  -  2q32.3   chr2:191602551-191724170 -  2q32.3   [Description]    (hg18-March_2006)
EnsemblSTAT4 - 2q32.3 [CytoView]
Mapping of homologs : NCBISTAT4 [Mapview]
OMIM152700   180300   600558   612253   
Gene and transcription
Gene : Genbank (Entrez)AB209043 AK299976 AK300868 AK301172 BC016694
Reference sequence (RefSeq transcript) :SRSNM_003151
Reference transcript : EntrezNM_003151
RefSeq genomic : SRSAC_000045 AC_000134 NC_000002 NG_012852 NT_005403 NW_001838863 NW_921585
RefSeq genomic : EntrezAC_000045 AC_000134 NC_000002 NG_012852 NT_005403 NW_001838863 NW_921585
Consensus coding sequences : CCDS NCBISTAT4
Cluster EST : UnigeneHs.80642 [ SRS ] Hs.80642 [ NCBI ]
Alternative Splicing : Fast-db (Paris)13862
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ14765 (SRS) Q14765 (Expasy) Q14765 (Uniprot)
With graphics : InterProQ14765
Splice isoforms : VarSplice FASTAQ14765(VarSplice FASTA)
Domaine pattern : Prosite (SRS)SH2 (PS50001)   
Domain pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (SRS)EF-hand-like_dom    p53-like_TF_DNA-bd    SH2    STAT_TF_alpha    STAT_TF_coiled-coil    STAT_TF_core    STAT_TF_DNA-bd    STAT_TF_DNA-bd_sub    STAT_TF_prot_interaction   
Domains : Interpro (EBI)EF-hand-like_dom    p53-like_TF_DNA-bd    SH2    STAT_TF_alpha    STAT_TF_coiled-coil    STAT_TF_core    STAT_TF_DNA-bd    STAT_TF_DNA-bd_sub    STAT_TF_prot_interaction   
Related proteins : CluSTrQ14765
Domain families : Pfam SRSSH2 (PF00017)    STAT_alpha (PF01017)    STAT_bind (PF02864)    STAT_int (PF02865)   
Domain families : Pfam SangerSH2 (PF00017)    STAT_alpha (PF01017)    STAT_bind (PF02864)    STAT_int (PF02865)   
Domain families : Pfam NCBIpfam00017    pfam01017    pfam02864    pfam02865   
Domain families : Smart EMBLSH2 (SM00252)  
Blocks (Seattle)Q14765
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD02779
Protein Interaction databases
DIP (DOE-UCLA)Q14765
IntAct (EBI)Q14765
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBISTAT4
SNP : GeneSNP UtahSTAT4
SNP : HGBaseSTAT4
Genetic variants : HAPMAPSTAT4
Somatic Mutations in Cancer : COSMICSTAT4 
Mutations and Diseases : HGMDSTAT4
Hereditary diseases : OMIM152700    180300    600558    612253   
Hereditary diseases : GENETests152700    180300    600558    612253   
Diseases : Genetic AssociationSTAT4
General knowledge
Homologs : HomoloGeneSTAT4
Homology/Alignments : Family Browser UCSCSTAT4
Phylogenetic Trees/Animal Genes : TreeFamSTAT4
Chemical/Protein Interactions : CTD6775
Keywords Ontology : AmiGOtranscription factor activity  signal transducer activity  calcium ion binding  protein binding  nucleus  nucleolus  cytoplasm  regulation of transcription, DNA-dependent  protein amino acid phosphorylation  signal transduction  JAK-STAT cascade  cell proliferation  cytokine-mediated signaling pathway  
Keywords Ontology : EGO-EBItranscription factor activity  signal transducer activity  calcium ion binding  protein binding  nucleus  nucleolus  cytoplasm  regulation of transcription, DNA-dependent  protein amino acid phosphorylation  signal transduction  JAK-STAT cascade  cell proliferation  cytokine-mediated signaling pathway  
Pathways : BIOCARTAIL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]    NO2-dependent IL 12 Pathway in NK cells [Genes]   
Pathways : KEGGJak-STAT signaling pathway
Other databases
Probes
Probes : ImagenesSTAT4 Related clones (RZPD - Berlin)
Literature
PubMed84 Pubmed reference(s) in Entrez
PubGeneSTAT4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:40:47 CET 2010
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