STEAP4 (STEAP4 metalloreductase)

2003-06-01  

Identity

HGNC
STEAP4
LOCATION
7q21.12
LOCUSID
79689
ALIAS
STAMP2,SchLAH,TIARP,TNFAIP9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79689
MIM: 611098
HGNC: 21923
Ensembl: ENSG00000127954

Variants:

dbSNP: 79689
ClinVar: 79689
TCGA: ENSG00000127954
COSMIC: STEAP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127954ENST00000301959Q687X5
ENSG00000127954ENST00000380079Q687X5
ENSG00000127954ENST00000414498C9JS50

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
235536082013Induction of STEAP4 correlates with 1,25-dihydroxyvitamin D3 stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue.25
183815742008Expression of six transmembrane protein of prostate 2 in human adipose tissue associates with adiposity and insulin resistance.18
256808602015STAMP2 increases oxidative stress and is critical for prostate cancer.16
184303672008Downregulation of STEAP4, a highly-expressed TNF-alpha-inducible gene in adipose tissue, is associated with obesity in humans.15
218495202011Decreased STAMP2 expression in association with visceral adipose tissue dysfunction.13
192891232009Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro.11
201270402010STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes.11
231792032013Six-transmembrane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity.11
216339112012Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis.10
285768712017STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper.9

Citation

Dessen P

STEAP4 (STEAP4 metalloreductase)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40604/steap4