STIM2 (stromal interaction molecule 2)

2012-10-01  

Identity

HGNC
LOCATION
4p15.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 57620
MIM: 610841
HGNC: 19205
Ensembl: ENSG00000109689

Variants:

dbSNP: 57620
ClinVar: 57620
TCGA: ENSG00000109689
COSMIC: STIM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109689ENST00000463501R4GMP0
ENSG00000109689ENST00000465503H0Y860
ENSG00000109689ENST00000467011H7C5A5
ENSG00000109689ENST00000467087A0A1X7SBY3
ENSG00000109689ENST00000473519H7C5K2
ENSG00000109689ENST00000477474H7C5C6
ENSG00000109689ENST00000478049R4GNC5
ENSG00000109689ENST00000494628R4GN82

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Calcium signaling pathwayKEGGhsa04020

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
160052982005STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.831
181600412007STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels.254
229142932012STIM proteins: dynamic calcium signal transducers.243
114633382001Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins.121
168607472006STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry.114
198439592009STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death.93
179057232008STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation.75
190198252009Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics.71
244924162014Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site.68
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62

Citation

Dessen P

STIM2 (stromal interaction molecule 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52904/stim2