STING1 (stimulator of interferon response cGAMP interactor 1)

2011-03-01  

Identity

HGNC
STING1
LOCATION
5q31.2
LOCUSID
340061
ALIAS
ERIS,MITA,MPYS,NET23,SAVI,STING,STING-beta,TMEM173,hMITA,hSTING

Other Information

Locus ID:

NCBI: 340061
MIM: 612374
HGNC: 27962
Ensembl: ENSG00000184584

Variants:

dbSNP: 340061
ClinVar: 340061
TCGA: ENSG00000184584
COSMIC: STING1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184584ENST00000330794Q86WV6
ENSG00000184584ENST00000510817J3QTB1
ENSG00000184584ENST00000650883A0A494C1N5
ENSG00000184584ENST00000651565A0A494C0W5
ENSG00000184584ENST00000651699Q86WV6
ENSG00000184584ENST00000652110J3QTB1
ENSG00000184584ENST00000652271Q86WV6
ENSG00000184584ENST00000652543A0A494C0T1

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
STING mediated induction of host immune responsesREACTOMER-HSA-1834941
IRF3-mediated induction of type I IFNREACTOMER-HSA-3270619
STAT6-mediated induction of chemokinesREACTOMER-HSA-3249367
Regulation of innate immune responses to cytosolic DNAREACTOMER-HSA-3134975
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
188181052008The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.428
218921742011The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells.314
256368002015Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.308
223945622012STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.261
237070652013The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.211
241198412013Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling.186
192854392009The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.149
227451332012TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination.112
261994182015Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses.95
268671742016The cGAS-STING Defense Pathway and Its Counteraction by Viruses.83

Citation

Dessen P

STING1 (stimulator of interferon response cGAMP interactor 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52153/sting1