Atlas of Genetics and Cytogenetics in Oncology and Haematology


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STING1 (stimulator of interferon response cGAMP interactor 1)

Identity

Alias_symbol (synonym)FLJ38577
NET23
ERIS
MPYS
STING
MITA
Other aliasSAVI
STING-beta
TMEM173
hMITA
hSTING
HGNC (Hugo) STING1
LocusID (NCBI) 340061
Atlas_Id 52153
Location 5q31.2  [Link to chromosome band 5q31]
Location_base_pair Starts at 139475528 and ends at 139482790 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)STING1   27962
Cards
Entrez_Gene (NCBI)STING1  340061  stimulator of interferon response cGAMP interactor 1
AliasesERIS; MITA; MPYS; NET23; 
SAVI; STING; STING-beta; TMEM173; hMITA; hSTING
GeneCards (Weizmann)STING1
Ensembl hg19 (Hinxton)ENSG00000184584 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184584 [Gene_View]  ENSG00000184584 [Sequence]  chr5:139475528-139482790 [Contig_View]  STING1 [Vega]
ICGC DataPortalENSG00000184584
TCGA cBioPortalSTING1
AceView (NCBI)STING1
Genatlas (Paris)STING1
WikiGenes340061
SOURCE (Princeton)STING1
Genetics Home Reference (NIH)STING1
Genomic and cartography
GoldenPath hg38 (UCSC)STING1  -     chr5:139475528-139482790 -  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STING1  -     -   [Description]    (hg19-Feb_2009)
GoldenPathSTING1 - - [CytoView hg19]  STING1 - - [CytoView hg38]
ImmunoBaseENSG00000184584
Mapping of homologs : NCBISTING1 [Mapview hg19]  STING1 [Mapview hg38]
OMIM612374   615934   
Gene and transcription
Genbank (Entrez)AK095896 AK129800 AK290661 AX775913 BC047779
RefSeq transcript (Entrez)NM_001301738 NM_001367258 NM_198282
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STING1
Alternative Splicing GalleryENSG00000184584
Gene ExpressionSTING1 [ NCBI-GEO ]   STING1 [ EBI - ARRAY_EXPRESS ]   STING1 [ SEEK ]   STING1 [ MEM ]
Gene Expression Viewer (FireBrowse)STING1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)340061
GTEX Portal (Tissue expression)STING1
Human Protein AtlasENSG00000184584-STING1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86WV6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86WV6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86WV6
Splice isoforms : SwissVarQ86WV6
PhosPhoSitePlusQ86WV6
Domains : Interpro (EBI)STING    STING_C    STING_C_sf   
Domain families : Pfam (Sanger)TMEM173 (PF15009)   
Domain families : Pfam (NCBI)pfam15009   
Conserved Domain (NCBI)STING1
DMDM Disease mutations340061
Blocks (Seattle)STING1
PDB (RSDB)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C   
PDB Europe4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C   
PDB (PDBSum)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C   
PDB (IMB)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C   
Structural Biology KnowledgeBase4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C   
SCOP (Structural Classification of Proteins)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C   
CATH (Classification of proteins structures)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C   
SuperfamilyQ86WV6
Human Protein Atlas [tissue]ENSG00000184584-STING1 [tissue]
Peptide AtlasQ86WV6
HPRD14173
IPIIPI00257059   IPI00964330   
Protein Interaction databases
DIP (DOE-UCLA)Q86WV6
IntAct (EBI)Q86WV6
FunCoupENSG00000184584
BioGRIDSTING1
STRING (EMBL)STING1
ZODIACSTING1
Ontologies - Pathways
QuickGOQ86WV6
Ontology : AmiGOautophagosome assembly  autophagosome membrane  activation of innate immune response  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  protein binding  nucleoplasm  mitochondrial outer membrane  endosome  autophagosome  peroxisome  endoplasmic reticulum membrane  endoplasmic reticulum membrane  endoplasmic reticulum membrane  Golgi apparatus  cytosol  plasma membrane  transcription factor binding  viral process  positive regulation of macroautophagy  protein kinase binding  protein kinase binding  integral component of endoplasmic reticulum membrane  cytoplasmic vesicle membrane  secretory granule membrane  ubiquitin protein ligase binding  positive regulation of protein binding  regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of type I interferon production  interferon-beta production  interferon-beta production  interferon-beta production  cyclic-di-GMP binding  cyclic-di-GMP binding  cellular response to interferon-beta  cytoplasmic pattern recognition receptor signaling pathway in response to virus  identical protein binding  protein homodimerization activity  neutrophil degranulation  innate immune response  innate immune response  innate immune response  positive regulation of transcription by RNA polymerase II  perinuclear region of cytoplasm  regulation of inflammatory response  positive regulation of DNA-binding transcription factor activity  protein complex oligomerization  defense response to virus  defense response to virus  cyclic-GMP-AMP binding  cyclic-GMP-AMP binding  cyclic-GMP-AMP binding  reticulophagy  cellular response to exogenous dsRNA  cellular response to exogenous dsRNA  cellular response to organic cyclic compound  integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane  
Ontology : EGO-EBIautophagosome assembly  autophagosome membrane  activation of innate immune response  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  protein binding  nucleoplasm  mitochondrial outer membrane  endosome  autophagosome  peroxisome  endoplasmic reticulum membrane  endoplasmic reticulum membrane  endoplasmic reticulum membrane  Golgi apparatus  cytosol  plasma membrane  transcription factor binding  viral process  positive regulation of macroautophagy  protein kinase binding  protein kinase binding  integral component of endoplasmic reticulum membrane  cytoplasmic vesicle membrane  secretory granule membrane  ubiquitin protein ligase binding  positive regulation of protein binding  regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of type I interferon production  interferon-beta production  interferon-beta production  interferon-beta production  cyclic-di-GMP binding  cyclic-di-GMP binding  cellular response to interferon-beta  cytoplasmic pattern recognition receptor signaling pathway in response to virus  identical protein binding  protein homodimerization activity  neutrophil degranulation  innate immune response  innate immune response  innate immune response  positive regulation of transcription by RNA polymerase II  perinuclear region of cytoplasm  regulation of inflammatory response  positive regulation of DNA-binding transcription factor activity  protein complex oligomerization  defense response to virus  defense response to virus  cyclic-GMP-AMP binding  cyclic-GMP-AMP binding  cyclic-GMP-AMP binding  reticulophagy  cellular response to exogenous dsRNA  cellular response to exogenous dsRNA  cellular response to organic cyclic compound  integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane  
NDEx NetworkSTING1
Atlas of Cancer Signalling NetworkSTING1
Wikipedia pathwaysSTING1
Orthology - Evolution
OrthoDB340061
GeneTree (enSembl)ENSG00000184584
Phylogenetic Trees/Animal Genes : TreeFamSTING1
HOGENOMQ86WV6
Homologs : HomoloGeneSTING1
Homology/Alignments : Family Browser (UCSC)STING1
Gene fusions - Rearrangements
Fusion : QuiverSTING1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTING1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STING1
dbVarSTING1
ClinVarSTING1
1000_GenomesSTING1 
Exome Variant ServerSTING1
ExAC (Exome Aggregation Consortium)ENSG00000184584
GNOMAD BrowserENSG00000184584
Varsome BrowserSTING1
Genetic variants : HAPMAP340061
Genomic Variants (DGV)STING1 [DGVbeta]
DECIPHERSTING1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTING1 
Mutations
ICGC Data PortalSTING1 
TCGA Data PortalSTING1 
Broad Tumor PortalSTING1
OASIS PortalSTING1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTING1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSTING1
Mutations and Diseases : HGMDSTING1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STING1
DgiDB (Drug Gene Interaction Database)STING1
DoCM (Curated mutations)STING1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STING1 (select a term)
intoGenSTING1
Cancer3DSTING1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612374    615934   
Orphanet23209   
DisGeNETSTING1
MedgenSTING1
Genetic Testing Registry STING1
NextProtQ86WV6 [Medical]
TSGene340061
GENETestsSTING1
Target ValidationSTING1
Huge Navigator STING1 [HugePedia]
snp3D : Map Gene to Disease340061
BioCentury BCIQSTING1
ClinGenSTING1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD340061
Chemical/Pharm GKB GenePA162405934
Clinical trialSTING1
Miscellaneous
canSAR (ICR)STING1 (select the gene name)
HarmonizomeSTING1
DataMed IndexSTING1
Probes
Litterature
PubMed179 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTING1
EVEXSTING1
GoPubMedSTING1
iHOPSTING1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Mar 11 19:33:40 CET 2020

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