STIP1 (stress induced phosphoprotein 1)

2011-02-01  

Identity

HGNC
STIP1
LOCATION
11q13.1
LOCUSID
10963
ALIAS
HEL-S-94n,HOP,IEF-SSP-3521,P60,STI1,STI1L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10963
MIM: 605063
HGNC: 11387
Ensembl: ENSG00000168439

Variants:

dbSNP: 10963
ClinVar: 10963
TCGA: ENSG00000168439
COSMIC: STIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168439ENST00000305218P31948
ENSG00000168439ENST00000305218V9HW72
ENSG00000168439ENST00000358794P31948
ENSG00000168439ENST00000536973F5GXD8
ENSG00000168439ENST00000538945P31948
ENSG00000168439ENST00000540887H0YGI8
ENSG00000168439ENST00000543847F5H783

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Prion diseasesKEGGko05020
Prion diseasesKEGGhsa05020

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10832corticosteroidsChemicalVariantAnnotationnot associatedPD27523435
PA443450AsthmaDiseaseVariantAnnotationnot associatedPD27523435

References

Pubmed IDYearTitleCitations
118774172002Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes.83
228248012013C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances.76
184853642008Structural studies on the co-chaperone Hop and its complexes with Hsp90.44
192548102009The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids.39
192548102009The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids.39
205019392010Stress-induced phosphoprotein 1 as a secreted biomarker for human ovarian cancer promotes cancer cell proliferation.32
214707702011RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation.31
178862922007STI1 promotes glioma proliferation through MAPK and PI3K pathways.26
228843692012Secreted stress-induced phosphoprotein 1 activates the ALK2-SMAD signaling pathways and promotes cell proliferation of ovarian cancer cells.23
156321282005Functional comparison of human and Drosophila Hop reveals novel role in steroid receptor maturation.19

Citation

Dessen P

STIP1 (stress induced phosphoprotein 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52069/stip1