STK10 (serine/threonine kinase 10)

2006-10-01  

Identity

HGNC
STK10
LOCATION
5q35.1
LOCUSID
6793
ALIAS
LOK,PRO2729
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6793
MIM: 603919
HGNC: 11388
Ensembl: ENSG00000072786

Variants:

dbSNP: 6793
ClinVar: 6793
TCGA: ENSG00000072786
COSMIC: STK10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072786ENST00000176763O94804
ENSG00000072786ENST00000520476H0YB71

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
192554422009LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.58
203062912010A three-stage genome-wide association study of general cognitive ability: hunting the small effects.36
232093042012Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.29
284305762017Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism.11
126399662003Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue.9
119030602002Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.5
238428452013STK10 missense mutations associated with anti-apoptotic function.3
271774952016Altered mitochondrial expression genes in patients receiving right ventricular apical pacing.1
219055012011Variations in the STK10 gene and possible associations with aspirin-intolerant asthma in a Korean population.0

Citation

Dessen P

STK10 (serine/threonine kinase 10)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43506/stk10