STK26 (serine/threonine kinase 26)

2014-09-01  

Identity

HGNC
STK26
LOCATION
Xq26.2
LOCUSID
51765
ALIAS
MASK,MST4

Other Information

Locus ID:

NCBI: 51765
MIM: 300547
HGNC: 18174
Ensembl: ENSG00000134602

Variants:

dbSNP: 51765
ClinVar: 51765
TCGA: ENSG00000134602
COSMIC: STK26

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134602ENST00000354719Q8NBY1
ENSG00000134602ENST00000394334Q9P289
ENSG00000134602ENST00000394335Q9P289
ENSG00000134602ENST00000481105B4E0Y9
ENSG00000134602ENST00000496850Q9P289

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
193862642009Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.74
173609712007PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway.60
292325562017MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma.43
243743102014Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.41
256428222015The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6.29
117418932002Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties.22
238892532013SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.19
128106712003The Ste20 kinase MST4 plays a role in prostate cancer progression.18
235418962013Structural mechanism of CCM3 heterodimerization with GCKIII kinases.14
248598102014MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway.14

Citation

Dessen P

STK26 (serine/threonine kinase 26)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54887/stk26